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- W2394262829 abstract "Objective It is to observe the curative effect of Captopril on hepatic fibrosis rats.Methods 60 Wistar rats were randomly divided into normal group, model group and treatment group.Hepatic fibrosis model rats were induced with CCl_4.Treatment group were given Captopril at the fourth week after the model induced.Transforming growth factor β_1(TGFβ_1) and platelet-derived growth factor(PDGF)-BB in rats' hepatic tissue were detected with immunohistochemical.The hepatic tissue patho-change was detected with HE staining.Results Compared with model group,the expressions of TGFβ_1 and PDGF-BB in hepatic tissue in treatment group were obviously debased(P0.05).The hepatic lobules were all incline to normal and the tissue intervals were all obviously thinned.Conclusion Captopril can effectively lighten liver injury and hepatic fibrosis degree.Its mechanism may be related to its inhibiting TGFβ_1 and PDGF-BB producing directly and indirectly." @default.
- W2394262829 created "2016-06-24" @default.
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- W2394262829 date "2005-01-01" @default.
- W2394262829 modified "2023-09-28" @default.
- W2394262829 title "Influence of Captopril on TGFβ_1 and PDGF-BB in hepatic fibrosis rats" @default.
- W2394262829 hasPublicationYear "2005" @default.
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