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• W2394267937 abstract "Objective To compare the pathologic characteristics of primary colorectal cancer (CRC) between American Caucasian and Chinese patients. Methods A retrospective study was undertaken. Data was collected from 690 patients in Cleveland Clinic Florida USA, and 870 patients in Nanfang Hospital in China from 1990 to 2000. All the patients with CRC were diagnosed by surgery and histology. Results Overall 36.3% of Caucasian patients vs. 26.0% of Chinese patients had lesions in the proximal colon and 63.7 % vs. 74.0% had cancers located on distal colorectum ( P 0.001). The median age was 72 years in Caucasian patients vs. 54 years in Chinese patients ( P 0.001). The proportion of histological types was not significantly different between two race groups ( P 0.05). The proportion of adenocarcinomas was significantly greater in proximal colon among Caucasian patients than among Chinese patients ( P 0.001). Overall, 16.7% in Caucasian patients vs. 40.2% in Chinese patients were differentiated adenocarcinoma ( P 0.001), 61.9% vs. 48.5% moderately differentiated ( P 0.001), and 21.4% vs. 11.3% poorly differentiated ( P 0.001). Higher proportion of poorly differentiatied cancer was in proximal colon in two groups. In staging, 5.4% of Caucasian patients vs. 1.3% of Chinese patients were stage 0 ( P 0.001), 34.8% vs. 18.9% were stage Ⅰ ( P 0.001), 29.9% vs. 33.2% were stage Ⅱ( P 0.05), 20.3% vs. 22.8% were stage Ⅲ( P 0.05), 9.6% vs. 17.0% were stage Ⅳ ( P 0.001). Later-stage was more frequently in the proximal colon than in the distal colorectum in two different race groups. Further Caucasian patients had higher proportion of later-stage than Chinese patients did in proximal colon cancer.Overall Chinese patients were more likely to be later-stage cancer than Caucasian patients were. Conclusions America Caucasian patients have a higher risk of proximal CRC, Chinese patients were more likely to have distal CRC, poorly differentiated, later-stage cancer was more frequently to be located in proximal colon, Chinese patients was more likely to be later-stage." @default.
• W2394267937 created "2016-06-24" @default.
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• W2394267937 date "2003-01-01" @default.
• W2394267937 modified "2023-09-24" @default.
• W2394267937 title "Comparison of pathologic characteristics of primary colorectal cancer between American Caucasian and Chinese patients" @default.
• W2394267937 hasPublicationYear "2003" @default.
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