Matches in SemOpenAlex for { <https://semopenalex.org/work/W2394268932> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2394268932 abstract "Objective:To study the effect and mechanism of arsenic trioxide(As2O3) with vitamin C(Vit C) on the subcutaneously transplanted tumor of drug resistant human lung tumors in nude mice.Method: The subcutaneously transplanted tumor models of drug resistant human lung tumors in nude mice were established and then were divided at random into 5 groups: NS,Vit C(250 mg·kg-1),As2O3(1.5,3.0 mg·kg-1),and combining As2O3 with Vit C.They were injected intraperitoneally for two weeks.The weight of mice and volume of tumor pre-and post-administration were measured.All mice were killed after administration,and measured the mass of tumor and calculated the tumor inhibition.Tumor tissue was examined by pathological method.RT-PCR and Western blot were used to detect the vascular endothelial growth factor and survivin.Result: The tumor inhibitory rate of Vit C,As2O3(1.5,3.0 mg·kg-1),and combining As2O3 with Vit C were 3.42%,42.3%,66.25%,79.93% accordingly,and the volume,mass of tumor were decreased after treatment,in contrast to the saline group,the differences were significant(P0.01).The tumor mass and volume were decreased in the test groups,more markedly in the combined drug group than single-drug groups.Moderate necrosis was found in tumor tissues.The expression of survivin mRNA and VEGF mRNA in the combination group was markedly lower than those in the other groups.The result of Western blot was also support RT-PCR's.Conclusion: Combined As2O3 and Vit C has stronger inhibition effect on tumor growth than single use of each drug,with a synergic anticancer effect on transplanted lung cancer in nude mice.Possible mechanism is related to the down-regulation of the expression of survivin and VEGF.Application of vitamin C and As2O3 might be a chemotherapy combination with low toxicity and efficient." @default.
- W2394268932 created "2016-06-24" @default.
- W2394268932 creator A5074678706 @default.
- W2394268932 date "2011-01-01" @default.
- W2394268932 modified "2023-09-28" @default.
- W2394268932 title "Anti-tumor Mechanism of Combining Arsenic Trioxide with Vitamin C on Subcutaneously Transplanted Tumor of Drug Resistant Human Lung Tumors in Nude Mice" @default.
- W2394268932 hasPublicationYear "2011" @default.
- W2394268932 type Work @default.
- W2394268932 sameAs 2394268932 @default.
- W2394268932 citedByCount "0" @default.
- W2394268932 crossrefType "journal-article" @default.
- W2394268932 hasAuthorship W2394268932A5074678706 @default.
- W2394268932 hasConcept C104317684 @default.
- W2394268932 hasConcept C121608353 @default.
- W2394268932 hasConcept C126322002 @default.
- W2394268932 hasConcept C142724271 @default.
- W2394268932 hasConcept C185592680 @default.
- W2394268932 hasConcept C190283241 @default.
- W2394268932 hasConcept C2775975398 @default.
- W2394268932 hasConcept C2776415932 @default.
- W2394268932 hasConcept C2777714996 @default.
- W2394268932 hasConcept C2780386689 @default.
- W2394268932 hasConcept C55493867 @default.
- W2394268932 hasConcept C71924100 @default.
- W2394268932 hasConcept C98274493 @default.
- W2394268932 hasConceptScore W2394268932C104317684 @default.
- W2394268932 hasConceptScore W2394268932C121608353 @default.
- W2394268932 hasConceptScore W2394268932C126322002 @default.
- W2394268932 hasConceptScore W2394268932C142724271 @default.
- W2394268932 hasConceptScore W2394268932C185592680 @default.
- W2394268932 hasConceptScore W2394268932C190283241 @default.
- W2394268932 hasConceptScore W2394268932C2775975398 @default.
- W2394268932 hasConceptScore W2394268932C2776415932 @default.
- W2394268932 hasConceptScore W2394268932C2777714996 @default.
- W2394268932 hasConceptScore W2394268932C2780386689 @default.
- W2394268932 hasConceptScore W2394268932C55493867 @default.
- W2394268932 hasConceptScore W2394268932C71924100 @default.
- W2394268932 hasConceptScore W2394268932C98274493 @default.
- W2394268932 hasLocation W23942689321 @default.
- W2394268932 hasOpenAccess W2394268932 @default.
- W2394268932 hasPrimaryLocation W23942689321 @default.
- W2394268932 hasRelatedWork W2010280862 @default.
- W2394268932 hasRelatedWork W2089180563 @default.
- W2394268932 hasRelatedWork W2094121299 @default.
- W2394268932 hasRelatedWork W2348446520 @default.
- W2394268932 hasRelatedWork W2350790671 @default.
- W2394268932 hasRelatedWork W2352609954 @default.
- W2394268932 hasRelatedWork W2369273274 @default.
- W2394268932 hasRelatedWork W2369571761 @default.
- W2394268932 hasRelatedWork W2413766976 @default.
- W2394268932 hasRelatedWork W2430684039 @default.
- W2394268932 hasRelatedWork W2464371131 @default.
- W2394268932 hasRelatedWork W2587635109 @default.
- W2394268932 hasRelatedWork W2883051989 @default.
- W2394268932 hasRelatedWork W3028699646 @default.
- W2394268932 hasRelatedWork W3029563487 @default.
- W2394268932 hasRelatedWork W3031074295 @default.
- W2394268932 hasRelatedWork W3031761558 @default.
- W2394268932 hasRelatedWork W3032447215 @default.
- W2394268932 hasRelatedWork W3149621156 @default.
- W2394268932 hasRelatedWork W72429244 @default.
- W2394268932 isParatext "false" @default.
- W2394268932 isRetracted "false" @default.
- W2394268932 magId "2394268932" @default.
- W2394268932 workType "article" @default.