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- W2394278573 abstract "Objective To explore the way of cell injured induced by rotenone in PC12 cells in order to provide the theoretical basis of neuroprotective drugs.Methods The cultivated PC12 cells were divided into control and 0.5 μmol·L-1 rotenone-treated groups.Cell viability was estimated by MTT 72 h after treatment.Cell apoptosis was examined by Hoechst 33342.Proteins were extracted from two cell groups,respectively.The maps of proteins were set up by DIGE system.The altered protein spots were identified with MALDI-TOF MS and database searching.Results MTT showed cell viability decreased significantly in 0.5 μmol·L-1rotenone-treated group compared with control group(P0.01).Hoechst33342 fluorescence staining showed that the ratio of apoptosis in rotenone-treated group increased significantly compared with control group(P0.01).DIGE revealed three protein spots were significantly changed in rotenone-treated cells compared with control(P0.01).MALDI-TOF MS analysis and NCBI database searching demonstrated them as γ-enolase,Tpi1 and eIF4A,respectively.Conclusion γ-enolase Tpil and eIF4A may involved in the cytotoxicity,which mybe the target of neuroprotective drugs." @default.
- W2394278573 created "2016-06-24" @default.
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- W2394278573 date "2008-01-01" @default.
- W2394278573 modified "2023-09-27" @default.
- W2394278573 title "Way of cell injured induced by rotenone in PC12 cells" @default.
- W2394278573 hasPublicationYear "2008" @default.
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