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- W2394279956 abstract "Objective:To study the allele frequencies and genotype distribution of the promoter of transforming growth factor-beta 1(TGF-β1) in patients with colorectal cancer and analyze the association of the genotype frequency with the serum level of TGF-β1 with colorectal cancer.Methods: One hundred and twenty patients with colorectal cancer and one hundred and thirty healthy controls were involved in this study.Allele specific polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) assay was used to determine the genotype TGF-β 1-800G/A and-509C/T,respectively.The serum level of TGF-β1 was determined by enzyme-linked immunosorbent assay(ELISA).Results: The colorectal cancer group showed significantly higher serum level of TGF-β1 than control group(P0.01).No significant difference was observed among cancer patients and controls in TGF-β1-800G/A genotype frequency(P0.05),but the difference was significant in TGF-β1-509C/T genotype frequency(P0.05).The relative risk analysis found that T allele carriers had higher risk of suffering colorectal cancer compared with the C allele carriers(OR=1.580,95%CI:1.109-2.251).The serum level of TGF-β1 in T allele carriers who suffered from colorectal cancer was significantly higher than those patients without T allele mutation(54.77±12.65 ng/mL vs 44.29±10.24 ng/mL,P0.01).Conclusion: TGF-β 1 gene-509C/T polymorphism is associated with the carcinogenesis of colorectal cancer.The TGF-β1 overexpresison increases the risk of suffering colorectal cancer in T allele carriers." @default.
- W2394279956 created "2016-06-24" @default.
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- W2394279956 date "2007-01-01" @default.
- W2394279956 modified "2023-09-23" @default.
- W2394279956 title "Association of TGF-β1 gene polymorphism with colorectal cancer" @default.
- W2394279956 hasPublicationYear "2007" @default.
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