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- W2394287487 abstract "Objective To elucidate the topogrophic and quantitative differences of the expression of epidermal growth factor receptor (EGFR) between laryngeal carcinoma and non-carcinoma tissue. Methods Immunohistochemical method (S-P staining) was used to examine the expression of EGFR in 45 cases of larygeal carcinoma and 21 cases of vocal cord Polyp, and for the quantitative determination, reverse transcri ption -polymerase chain reaction technique (RT-PCR) was applied in 21 cases of laryngeal careinoma and para-carcinoma hssue, as well as 10 cases of vocal cord poly. Results Those brown particles which were positive EGFR were mainly located in the cell membrane. In the samples of vocal cord polyp, the positive cells stained in EGFR were demonstrated in the hasal cell layer, while in the larygeal carcinoma samples, all the positive cells were diffusely localized. The expression levels of EGFR-mRNA in the larungeal carcinoma (0.967?.865) and paracarcinoma tissue (0.869?.734) were significantly higher than that in the vocal cord polyp (0.205?.047)(p0.05). Conclusion The overexpression and abnormal distribution of EGFR are the characteristic presentations of laryngeal carcinoma. The determination of EGFR-mRNA may be helful in diagnosis of laryngeal carcinoma." @default.
- W2394287487 created "2016-06-24" @default.
- W2394287487 creator A5090614546 @default.
- W2394287487 date "2000-01-01" @default.
- W2394287487 modified "2023-09-28" @default.
- W2394287487 title "Topographic and quantitative examination of epidermal growth factor receptor in laryngeal carcinomas" @default.
- W2394287487 hasPublicationYear "2000" @default.
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