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- W2394288080 abstract "Objective: To study the Solid Self-micro-emulsifying Drug Delivery System(SSMEDDS) of Etoposide(VP-16) and its pharmacokinetic characteristics in rats to improve its bioavailability. Methods: The recipe of SSMEDDS of VP-16 was optimized by studying the pseudoternary phase diagram,the self-emulsifying rate and the particle size.Dissolution rates of VP-16 loaded SSMEDDS were investigated in order to validate the efficiency.The plasma concentrations of VP-16 were detected at the preplanned intervals following intragastric administration of a single dose of 20 mg·kg-1 VP-16 to rats.The plasma concentration of VP-16 was determined by HPLC.Results: After dilution of the developed VP-16 SSMEDDS with water,the size of the micro-emulsion was determined to be(21.8±1.5) nm.The preparation of VP-16 SSMEDDS dissoluted more than 95% at 45 min.AUC were 12.20,8.25 and 10.49 mg·h·L-1,respectively,for VP-16 SSMEDDS,its raw material and commercial preparation given to rats.Conclusion: There exist significant improvements in the bioavailability of VP-16 in SSMEDDS." @default.
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- W2394288080 date "2011-01-01" @default.
- W2394288080 modified "2023-09-27" @default.
- W2394288080 title "Preparation of Etoposide Solid Self-microemulsifying Drug Delivery System and Its Bioavailability in Rats" @default.
- W2394288080 hasPublicationYear "2011" @default.
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