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- W2394306502 abstract "AIM:To investigate the role of recombinant E.coli LLO/WT1 in inducing the maturation of human peripheral blood dendritic cells(DC)and promoting WT1+ tumor resolving effect of the activated T cells.METHODS:After stimulated by E.coli LLO/WT1 and E.coli respectively,the surface molecules expression of DC was determined by flow cytometry;the proliferation and WT1+ SGC-7901 cells resolving effect of the activated T cells were determined by MTT.The concentration of IL-12 and IFN-γ in the supernatant of DC and co-cultured DC and T cells were determined by ELISA respectively.RESULTS:Compared with E.coli,E.coli LLO/WT1 stimulated DC expressing higher level of CD83,CD86 and HLA-DR,the positive rates were 78.1%,83.4%,93.2% and 65.8%,61.2%,75.8%;the activated DC secreted higher level of IL-12 also,the concentration of IL-12 in the supernatant was(270.42±3.85)and(204.17±4.23)ng/L(P0.05).E.coli LLO/WT1 activated DC promoted more autogenic T cell proliferation and secreted higher level IFN-γ than E.coli activated DC,the concentration of IFN-γ in the supernatant was(86.32±2.00)and(44.71±1.45)ng/L(P0.05);and the proliferated T cells resolved more WT1+ SGC-7901 cells,the killing rates were 68.44±3.78 and 36.76±2.63(P0.05).CONCLUSION:Recombinant E.coli LLO/WT1 effectively stimulates human peripheral blood DC maturation and promote WT1+ specific anti-tumor T cell immunity." @default.
- W2394306502 created "2016-06-24" @default.
- W2394306502 creator A5081865326 @default.
- W2394306502 date "2009-01-01" @default.
- W2394306502 modified "2023-09-23" @default.
- W2394306502 title "Recombinant E.coli LLO/WT1 induces the maturation of dendritic cell and promotes specific anti-tumor immunity" @default.
- W2394306502 hasPublicationYear "2009" @default.
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