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- W2394313402 abstract "Objective:To investigate the effect of Mifepristone on the expression of insulin-like growth factor-Ⅱ(IGF-Ⅱ)mRNA in human villus and decidua,and the relationship of IGF-Ⅱ to early pregnancy and abortion. Methods: Villus and decidua samples were obtained from 20 medical abortion patients(medicine group)and 20 surgical abortion patients(control group). Quantitative reverse transcription-polymerase chain reaction(RT-PCR) assay was utilized to determine the level of mRNA expression of IGF-Ⅱ in two groups.The morphology and the glycogen content in all samples were investigated by histochemistry and image analysis technology. Results: The levels of IGF-ⅡmRNA in villus and decidua in medicine group were significantly decreased,compared with those in control group(P0.05,P0.01).The glycogen contents in villus and decidua in control group were abundant, but insufficient in medicine group(P0.05, P0.01). Conclusion:Mifepristone may influence placental function,and impede embryo growth by inhibiting the expression of IGF-Ⅱ gene in villus and decidua in early pregnancy." @default.
- W2394313402 created "2016-06-24" @default.
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- W2394313402 date "2004-01-01" @default.
- W2394313402 modified "2023-09-28" @default.
- W2394313402 title "Effect of Mifepristone on the Expression of Insulin-like Growth Factor-II mRNA in Human Villus and Decidua" @default.
- W2394313402 hasPublicationYear "2004" @default.
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