Matches in SemOpenAlex for { <https://semopenalex.org/work/W2394313837> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2394313837 abstract "Objective: To evaluate the effects of PD145065(non selective endothelin(ET)receptor antagonist)on injured spinal cord and explore mechanisms of how ET plays a role in secondary injury following spinal cord injury(SCI).Methods:Spinal cord of rat was traumatized by compression(50g,1min).PD145065 or vehicle was administered intrathecally 10 minutes before SCI.Alterations of spinal cord blood flow(SCBF),molondialdehyde(MDA),the total content of intracellular calcium([Ca 2+ ] i),Evans blue(EB),and water in spinal cord were inspected.Results:SCBF of injured area decreased obviously 5 minutes after SCI.SCBF was 75.23±9.21% of baseline 5 minutes after SCI,57.06±7.35% 2 hours.SCBF of adjacent area decreased lower.SCBF was 79.82±7.98% of baseline 30 minutes after SCI.SCBF of injured and adjacent areas did not recover 4 hours after SCI.The contents of MDA,[Ca 2+ ] i,EB and water in traumatized spinal cord were significantly more than that of sham( P0.05 )。PD145065 ameliorated SCBF of injured area obviously and abolished the decrease of SCBF of adjacent area.The contents of MDA,[Ca 2+ ] i,EB and water in spinal cord of PD145065 treated group were significantly less than that of saline treated group( P0.05 ).Conclusion:PD145065 has protective effects on traumatized spinal cord in early phase.ET and its receptors may play a role in secondary injury following SCI by multiple pathways.ETA/ETB receptor antagonist may be useful in treatment of clinical SCI." @default.
- W2394313837 created "2016-06-24" @default.
- W2394313837 creator A5012344629 @default.
- W2394313837 date "2001-01-01" @default.
- W2394313837 modified "2023-09-23" @default.
- W2394313837 title "Protective Effects of Endothelin Receptor Antagonist on Traumatized Spinal Cord in Rats" @default.
- W2394313837 hasPublicationYear "2001" @default.
- W2394313837 type Work @default.
- W2394313837 sameAs 2394313837 @default.
- W2394313837 citedByCount "0" @default.
- W2394313837 crossrefType "journal-article" @default.
- W2394313837 hasAuthorship W2394313837A5012344629 @default.
- W2394313837 hasConcept C118552586 @default.
- W2394313837 hasConcept C126322002 @default.
- W2394313837 hasConcept C141071460 @default.
- W2394313837 hasConcept C144980905 @default.
- W2394313837 hasConcept C170493617 @default.
- W2394313837 hasConcept C2776885963 @default.
- W2394313837 hasConcept C2777397205 @default.
- W2394313837 hasConcept C2778122271 @default.
- W2394313837 hasConcept C2778334475 @default.
- W2394313837 hasConcept C2779632786 @default.
- W2394313837 hasConcept C2780775167 @default.
- W2394313837 hasConcept C42219234 @default.
- W2394313837 hasConcept C71924100 @default.
- W2394313837 hasConceptScore W2394313837C118552586 @default.
- W2394313837 hasConceptScore W2394313837C126322002 @default.
- W2394313837 hasConceptScore W2394313837C141071460 @default.
- W2394313837 hasConceptScore W2394313837C144980905 @default.
- W2394313837 hasConceptScore W2394313837C170493617 @default.
- W2394313837 hasConceptScore W2394313837C2776885963 @default.
- W2394313837 hasConceptScore W2394313837C2777397205 @default.
- W2394313837 hasConceptScore W2394313837C2778122271 @default.
- W2394313837 hasConceptScore W2394313837C2778334475 @default.
- W2394313837 hasConceptScore W2394313837C2779632786 @default.
- W2394313837 hasConceptScore W2394313837C2780775167 @default.
- W2394313837 hasConceptScore W2394313837C42219234 @default.
- W2394313837 hasConceptScore W2394313837C71924100 @default.
- W2394313837 hasLocation W23943138371 @default.
- W2394313837 hasOpenAccess W2394313837 @default.
- W2394313837 hasPrimaryLocation W23943138371 @default.
- W2394313837 hasRelatedWork W1509473600 @default.
- W2394313837 hasRelatedWork W184081802 @default.
- W2394313837 hasRelatedWork W2024325274 @default.
- W2394313837 hasRelatedWork W2084445731 @default.
- W2394313837 hasRelatedWork W2353673807 @default.
- W2394313837 hasRelatedWork W2353968198 @default.
- W2394313837 hasRelatedWork W2356719916 @default.
- W2394313837 hasRelatedWork W2358298401 @default.
- W2394313837 hasRelatedWork W2359358638 @default.
- W2394313837 hasRelatedWork W2369001643 @default.
- W2394313837 hasRelatedWork W2373137138 @default.
- W2394313837 hasRelatedWork W2381071281 @default.
- W2394313837 hasRelatedWork W2384276435 @default.
- W2394313837 hasRelatedWork W2389025602 @default.
- W2394313837 hasRelatedWork W2389594315 @default.
- W2394313837 hasRelatedWork W2390565899 @default.
- W2394313837 hasRelatedWork W2392784351 @default.
- W2394313837 hasRelatedWork W2396301014 @default.
- W2394313837 hasRelatedWork W3140918790 @default.
- W2394313837 hasRelatedWork W584590172 @default.
- W2394313837 isParatext "false" @default.
- W2394313837 isRetracted "false" @default.
- W2394313837 magId "2394313837" @default.
- W2394313837 workType "article" @default.