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- W2394328032 abstract "Objective To observe the effect of hepatitis C virus-F(HCV-F) gene on transcription activition of c-myc promoter and to explore the role of HCV-F on pathogenesis of hepatocarcinogenesis.Methods The luciferase reporter plasmids of c-myc promoter were constructed and cotransfected into HepG 2 cells with HCV-F and HCV-C expression plasmids.The transactivition of c-myc promoter was assayed by luminometer.Results HCV-C exhibited a distinct promotion activity to c-myc promoter,with a seven-folds increase of c-myc promoter transactivity compared to that of the control group.HCV-F showed less promotion activity and enhanced luciferase activity about three-folds increse of c-myc promoter.At a range of 2 to 10 μg,the enhancement of c-myc promoter was observed to be dose-dependent only with HCV-C not HCV-F.ConclusionHCV-F exhibits less promotion activity for c-myc promoter than HCV-C,which does not posses all functions of HCV-C protein." @default.
- W2394328032 created "2016-06-24" @default.
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- W2394328032 date "2010-01-01" @default.
- W2394328032 modified "2023-09-23" @default.
- W2394328032 title "Effect of HCV-F gene on transcription activation of c-myc promoter" @default.
- W2394328032 hasPublicationYear "2010" @default.
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