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- W2394329672 abstract "Objective To observe the alteration of anti-inflamatory cytokines (IL-10 and TGF-β 1)during acute pancreatitis and to confirm the effect of Somatostatin on modulation of cytokines in experimental pancreatitis.Methods SD male rats were divided into 3 groups:(1)normal control (n=6);(2)acute pancreatitis induced by ductal injection with 5% sodium cholate sulfur at the dose of 1.0?ml·kg -1 (n=10);(3)administration of somatostatin at the dose of 20?μg·kg -1 intravenourly for treatment of acute pancreatitis (n=10).The rats in group 2 and 3 were killed at 2,6 and 24 hours after operation.Blood samples were taken for measurement of IL-10,TGF-β 1(by ELISA),and the weights of pancreas were also tested.Results Serum IL-10 and TGF-β 1 in control group were(32.05±14.87)ng·L -1 and(66.4±13.20)ng·L -1 respectively.Twenty four hours after pancreatits was induced,serum IL-10 and TGF-β 1 in group 2 were(68.13±19.90)ng·L -1 and(103.77±28.95)ng·L -1 respectively.Comparing to normal rats,serum levels of IL-10 and TGF-β in group 2 increased significantly after 24 hours(P0.05).In group 3,after treatment by somatostatin,serum levels of IL-10 and TGF-β 1 were(42.2±14.55)ng·L -1 and(45.98±18.10)ng·L -1 ,which were significantly lower than that in group 2(P0.05).Conclusion Anti-inflammatory cytokines as IL-10 and TGF-β 1 increased remarkably in acute pancreatitis.This result indicate that there is a potential compensatory inflammation response syndrome,and somatostatin can inhibit the anti-inflammatory response syndrome in experimental acute pancrea~titis." @default.
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- W2394329672 date "2001-01-01" @default.
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- W2394329672 title "Regulation of somatostatin on alteration of anti-inflammatory cytokine in rats with acute pancreatitis" @default.
- W2394329672 hasPublicationYear "2001" @default.
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