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- W2394333298 abstract "Objective: To evaluate the clinical significance of interleukin-8 (IL-8) gene expression in breast cancer.Methods:The IL-8 mRNA was measured by a real-time quantitative PCR in 46 cases of breast cancer and adjuvant normal breast tissues. The ratio of tumor to normal tissue (T/N) of IL-8 expression was then calculated for each case. This value was correlated with the clinical-pathological parameters.Results:IL-8 mRNA was detectable in all tumors tested. Using T/N ratio ≥2 as cut-off point, 65.2 % (30/46 cases) of tumors were defined as high expression. Significant correlation was found between the T/N ratio and histopathology, stage of disease and lymph node involvement.IL-8 expression was not significantly related to the patient′s age.Conclusion:The IL-8 gene was highly expressed in breast cancer and the increased expression was more frequent in early stages than in late stages." @default.
- W2394333298 created "2016-06-24" @default.
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- W2394333298 date "2003-01-01" @default.
- W2394333298 modified "2023-09-24" @default.
- W2394333298 title "CLINICAL SIGNIFICANCE OF INTERLEUKIN-8 GENE EXPRESSION IN BREAST CANCER" @default.
- W2394333298 hasPublicationYear "2003" @default.
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