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- W2394334179 abstract "Objective To observe the effect of survived and migrated bone marrow MSC on Ach level and AchE activity in VaD rats.Methods Seventy-two Wistar rats were divided into control, model and treatment groups(24in each group).A VaD rat model was established.The survived and migrated bone marrow MSC and learning-memory ability,Ach level and AchE activity were assayed 4and 8weeks after 0.5ml of bone marrow MSC was transplanted into the carotid artery. Results The bone marrow MSC were widely distributed in the brain tissue of VaD rats,especially in hippocampus and cerebral cortex.The learning-memory ability was significantly lower in model group and treatment group than in control group(P0.01)whereas the learning-memory ability,Ach level and AchE activity were significantly higher in treatment group than in model group(P0.01).Conclusion Bone marrow MSC can migrate to the ischemia-injured areas,improve the cholinergic system function,regulate the Ach metabolism,repair the ischemia-injured brain tissues and strengthen the learning-memory ability of VaD rats." @default.
- W2394334179 created "2016-06-24" @default.
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- W2394334179 date "2014-01-01" @default.
- W2394334179 modified "2023-09-23" @default.
- W2394334179 title "Survival and migration of bone marrow MSC in brain of VaD rats and their effect on cholinergic system" @default.
- W2394334179 hasPublicationYear "2014" @default.
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