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- W2394334865 abstract "To investigate the possible mechanism of interaction of IL-10 and IL-10 receptor(IL-10R) and modulation of feto-maternal tolerance,multiple injection of the anti-IL-10R antibody was given intraperitoneally into pregnant BALB/c×C57BL/6 mice and multiple administration of recombinant mouse IL-10 was performed intraperitoneally into pregnant NOD×C57BL/6 mice at embryonic days E4.5,E6.5,E8.5.The proportion of decidual NKG2D+TGF-β-NK cells and the percentage of embryo resorption were determined on embryonic day E10.5.It was found that anti-IL-10R antibody administration significantly increased the proportion of decidual NKG2D+TGF-β-NK cells and the percentage of embryo resorption was significantly increased accordingly.In contrast,exogenous IL-10 treatment significantly decreased the percentage of decidual NKG2D+TGF-β-NK cells in NOD×C57BL/6 mice to a level comparable to that in BALB/c×C57BL/6 mice,and decreased the percentage of embryo resorption.These results suggest that IL-10 and IL-10R interaction may modulate the proportion of decidual NKG2D+TGF-β-NK cells and maintain it at a low level,and this status seems to be beneficial for the success of allogeneic pregnancy." @default.
- W2394334865 created "2016-06-24" @default.
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- W2394334865 date "2011-01-01" @default.
- W2394334865 modified "2023-09-24" @default.
- W2394334865 title "IL-10 maintains a low level of decidual NKG2D~+TGF-β~-NK cells and is beneficial for pregnancy success" @default.
- W2394334865 hasPublicationYear "2011" @default.
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