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- W2394339944 abstract "Objective:To investigate the impacts of radiobiological effect of protraction fraction time in IMRT on human nasopharyngeal carcinoma cell line CNE1. Methods: Human nasopharyngeal carcinoma cell line (CNE1) was irradiated with protocols of increasing dose delivery protraction by different models: (A)acute irradiation model: the cell were irradiated at 0,1,2,4,6,8Gy dose level by 6MV X ray, 2Gy/min.(B)IMRT model with the same dose level and rate with acute irradiation group:(B1)irradiation in 15 min by 2 fractions.(B2)irradiation in 15 min by 8 fractions.(B3)irradiation in 20 min by 15 fractions.(B4)irradiation in 30 min by 22 fractions. Clonogenic cell survival analysis was performed after irradiation experiments. The values of Dq,Do and SF2 were caculated according to thesingle-hit multi-target group.AgNORs staining was used to determine the cell repopulation dynamics. Results: The cell survival rates showed significant increase in IMRT model compared to acute irradiation and had a significant increase in the group with delivery time more than 15 minutes.The values of Do in Group A,B2,B4 were 0.56Gy,0.60Gy and 0.70Gy,Dq were 1.18Gy,1.24Gy and 1.30Gy,SF2 were 0.209,0.261 and 0.324,respectively. There was no significant difference among both post-radiation groups and different periods after radiation compared to acute group. Conclusion: Even at fraction times of 15-30 minutes the protracted dose delivery increases the survival rates in cell culture. Besides, there is a tendency that the survival rate increases if the fraction dose delivery time becomes longer. The altered survival rates indicate the importance of the dose rate in the effect of IMRT. The cell repopulation dynamics showed no change in IMRT compared to conventional application in our research. More researches are needed to discuss the results." @default.
- W2394339944 created "2016-06-24" @default.
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- W2394339944 date "2009-01-01" @default.
- W2394339944 modified "2023-09-26" @default.
- W2394339944 title "Radiobiological impacts of protraction fraction time on human nasopharyngeal carcinoma cell line CNE1" @default.
- W2394339944 hasPublicationYear "2009" @default.
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