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- W2394345087 abstract "Objective To observe the effects of IFN-α and TGF-β1 on telomerase activity and apoptosis of ovarian cancer SKOV3 cell line, and to explore their anti-cancer mechanism. Methods The changes of telomerase activity of SKOV3 cell line treated with IFN-α or /and TGF-β1 were detected by PCR ELISA method. Apoptosis was also determined by FCM method. The biological function of TGF-β1 on SKOV3 cell was studied by tumor formation assay in nude mouse and immunohistochemistry. Results IFN-α inhibited the growth of SKOV3 cell and down-regulated its telomerase activity. However, TGF-β1 increased the growth of SKOV3 cell and up-regulated its telomerase activity both in vitro and in vivo. Neither IFN-α nor TGF-β1 seemed to induce apoptosis in SKOV3 cell line. Conclusion That IFN-α inhibited telomerase activity in SKOV3 cell line is an important mechanism that may play a key role in the anti-tumor therapy for ovarian cancer. TGF-β1 can stimulate the growth of SKOV3 cells both in vitro and in vivo." @default.
- W2394345087 created "2016-06-24" @default.
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- W2394345087 date "2003-01-01" @default.
- W2394345087 modified "2023-09-22" @default.
- W2394345087 title "The effects of IFN-α and TGF-β1 on telomerase activity of ovarian cancer cell line SKOV3" @default.
- W2394345087 hasPublicationYear "2003" @default.
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