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- W2394349353 abstract "Objectivve: To evaluate relationship betweem the expression of both vascular endothelial growth factor (VEGF), and its receptor, flt 1, and MVD or metastasis in ovarian carcinoma tissues. Methods: Fifty three epithelial ovarian cancer tissues were stained immunohistochemically by anti VEGF, anti flt 1 and anti CD34,endothelial markers. Microvessel density (MVD) was counted in a ×200 field in the most active area of neovascularization. Quantitative and semi quantitative analysis were carried out for the related reference. Results: In fifty three ovarian cancer specimens, fourty were VEGF staining positive. The positive substance lies in cytoplasm and membrane of neoplasm cells. Thirty six were flt 1 staining positive and the positive substance lies in cytoplasm and membrane of the neo vascular endothelial cell inside the stroma of the neoplasm or around the neoplasm nest. VEGF and flt 1 expressions were related with lymph node metastases ( P 0 05). MVD was related with lymph node metastases and VEGF expression ( P 0 01). Conclusion: VEGF and flt 1 are of importance in the development of ovarian carcinoma and promote angiogenesis." @default.
- W2394349353 created "2016-06-24" @default.
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- W2394349353 date "2002-01-01" @default.
- W2394349353 modified "2023-09-24" @default.
- W2394349353 title "Relationship between the expression of both vascular endothelial growth factor, and its receptor, flt-1, and angiogeneis in ovarian carcinoma" @default.
- W2394349353 hasPublicationYear "2002" @default.
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