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- W2394354433 abstract "Aim To explore new ways for developing anticancer drugs by the separation of pigment from Fusarium species JN158( Fusarium sp JN158),the identification of its structure,the screening of anticancer components and the study of its partial mechanism.Methods Pigment separation was done by HPLC,structural analysis by UV,IR,NMR,the screening of anticancer activity by MTT. Western blot was used to analyze the protein expression of CyclinD1,NF-κB,VEGF in tumor cells. Results The results showed that the pigment from Fusarium produced a total of six different peaks,of which peak Ⅵ was the anthocyanins. Its molecular weight is about 382,molecular formula is C17H18O10. According to investigation,this pigment was probably a new compound,which could inhibit the proliferation of MCF-7 cells markedly( IC50:0. 011mmol·L- 1,P 0. 05; the control medicine ube-nimex IC50: 10 mmol·L- 1) in a concentration-dependent manner,and had no effect on human umbilical cord intravenous endotheliocyte( HUVEC). The influence on the gene expression of CyclinD1,NF-κB,VEGF in MCF-7 cells varied with the concentration of this compound. The Western blot results showed that VI pigment compound inhibited CyclinD1, NF-κB,VEGF gene expression( P 0. 05 or 0. 01),compared with the control group. Conclusion The Ⅵ pigment compound from Fusarium sp JN158 could inhibit MCF-7 proliferation by inhibiting CyclinD1,NF-κB,VEGF gene expression. The compound may be a promising compound against breast cancer." @default.
- W2394354433 created "2016-06-24" @default.
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- W2394354433 date "2014-01-01" @default.
- W2394354433 modified "2023-09-22" @default.
- W2394354433 title "Inhibitory effect of pigment produced by Fusarium sp JN158 on MCF-7 cell proliferation" @default.
- W2394354433 hasPublicationYear "2014" @default.
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