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- W2394355259 abstract "Objective To provide an animal model of intracranial tumor for the further study of cerebral glioma.Methods The glioma cell line C6 cells were cultured and 15 μl cultural fluid containing 1×106 C6 cells was sterotactically implanted into the left caudate nuclei in 19 rats.The changes in the behavior and body weight after implantation were observed and recorded in all the rats.MRI scanning was performed in 10 rats chosen randomly from those 19 rats 3 weeks after the implantation and then these 10 rats were sacrificed in order to take the brains which were pathologically examined.The other rats continuously observed until death.Results No tumor was found in the brain of 1 rat 60 days after the implantation.The tumors were found by MRI and autopsy in the other 18 rats.The tumors were confirmed by the pathological examination which showed that the tumors grew invasively in the brain and had newborn blood vessels.The expression of glial fibrillary acidic protein was positive in the tumors.The rats with tumors survived from 25 to 47 days [mean,(32.78±2.34) days].Conclusion Stereotactic implantation of C6 cells into the rats caudate nucleus can make a stable animal model of the intracranial glioma,which may satisfy experimented study of glioma." @default.
- W2394355259 created "2016-06-24" @default.
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- W2394355259 date "2012-01-01" @default.
- W2394355259 modified "2023-09-26" @default.
- W2394355259 title "Establishment of the Model of Intracerebral C6 Glioma in Rats" @default.
- W2394355259 hasPublicationYear "2012" @default.
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