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- W2394367987 abstract "Objective To observation the expression of Toll-like receptor mRNA,composition of intestinal flora,bacterial translocation and their relationship in rats with antibiotic induced diarrhea.Methods The dynamic changes of expression of Toll-like receptor mRNA were detected by reverse transcription polymerase chain reaction(RT-PCR)in mesenteric lymph nodes,liver,spleen and intestinal tissues.The number of intestinal Bifidobacterium,Lactobacillus,Enterobacteriaceae,Enterococci,and the number of translocating bacterial in mesenteric lymph nodes,liver and spleen were determined by bacterial culture.Results In the early stage of diarrhea induced by antibiotics,the expression of Toll-like receptor mRNA was inhibited,the imbalance and translocation of intestinal flora was observed.The bacterial translocations were different in mesenteric lymph nodes,liver and spleen.With the interference of Lactobacillus,the inhibited expression of Toll-like receptor mRNA and bacterial translocation were recovered.Meanwhile with the attack of Enterococci,inhibited expression of Toll-like receptor mRNA and bacterial translocation were further deterioration.Conclusions Antibiotic could induce diarrhea,inhibit expression of Toll-like receptor mRNA,lead to gut microflora imbalance and bacterial translocation.Early intervention with Lactobacillus may provide protective effect." @default.
- W2394367987 created "2016-06-24" @default.
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- W2394367987 date "2011-01-01" @default.
- W2394367987 modified "2023-09-25" @default.
- W2394367987 title "The relationship of expression of Toll-like receptor mRNA,composition of intestinal flora,and bacterial translocation in rat with antibiotic induced diarrhea" @default.
- W2394367987 hasPublicationYear "2011" @default.
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