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- W2394369938 abstract "Objective To observe if pulmonary function deteriorates in the second week of hyaline membrane disease(HMD) of neonates and if it is necessary to administer surfactant repeatedly and its effect.Methods Eighty-nine cases of HMD neonates born in our hospital in past three years were selected in this study.Their clinical information was retrospectively analyzed.They were assigned into three groups according to whether surfactant was given and the timing of administration,early administration group,late repeatedly administration group and non administration group.Their general condition,mechanical ventilation status,respiratory severity score(RSS) and prognosis were analyzed.Results Sixteen neonates(18%) developed postsurfactant slump and surfactant therapy was repeated in the second week after birth.The neonates in late repeatedly administration group were significantly more premature(gestational age 31.0±1.5 w) and had significantly lower birth weights(1 734±165 g) compared to neonates in other groups.Their incidence and mortality of intraventricular hemorrhage(IVH),retinopathy of prematurity(ROP) and bronchopulmonary dysplasia(BPD) were significantly higher than neonates in other groups and needed longer hospitalization.They also required longer and various forms of respiratory support.There was a significant decrease in the accumulative respiratory severity score within 48 hours after the late repeated surfactant administration.Conclusion Postsurfactant slump can be observed in HMD patients because of exhaustion of pulmonary surfactant in second week of RDS and it can be treated by administering surfactant repeatedly.This observation is useful for the comprehensive evaluation of progression of RDS." @default.
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- W2394369938 date "2008-01-01" @default.
- W2394369938 modified "2023-09-24" @default.
- W2394369938 title "The repeat administration of surfactant in late stage of neonatal hyaline membrane disease" @default.
- W2394369938 hasPublicationYear "2008" @default.
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