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- W2394382631 abstract "Objective:To investigate the effects of C_(60)-nitrogen mustard on the growth and metastasis of gastric cancer in nude mice.Methods:Forty male BALB/c nude mice were orthotopically transplanted with subcutaneous tumors and randomly divided into four groups as follows: NS group (n=10), C_(60) group (n=10), nitrogen mustard group (n=10) and C_(60)-nitrogen mustard group (n=10).Different drugs were administered intraperitoneally.Mice were sacrificed at the 9 th week after operation.Implanted tumors and metastases were observed macroscopically and histologically.Serum CEA density was detected by using radio-immunity method.Results:Group C_(60)-nitrogen mustard showed a statistically significant difference from the NS group in tumor growth (P0.05).Compared to nitrogen mustard group, C_(60)-nitrogen mustard group showed a statistically significant difference in lymph-node metastasis (P0.05).The tumor inhibition rates of NS group, C_(60) group, nitrogen mustard group and C_(60)-nitrogen mustard group were 0%, 4.6%, 36.2% and 41.4%.The levels of serum CEA were 32.6±4.5ng/ml, 30.5±4.8ng/ml, 17.9±4.1ng/ml and 16.3±3.3ng/ml.The rates of lymph-node metastases were 90%, 90%, 70% and 20%.The rates of liver metastases were 80%, 80%, 70% and 20%.Conclusion:C_(60)-nitrogen mustard has inhibitory effects on growth and metastasis of human gastric tumor in nude mice, especially in lymph-node metastases." @default.
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- W2394382631 date "2007-01-01" @default.
- W2394382631 modified "2023-09-23" @default.
- W2394382631 title "Effects of C_(60)-nitrogen mustard on the growth and metastasis of gastric cancer in nude mice" @default.
- W2394382631 hasPublicationYear "2007" @default.
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