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- W2394396254 abstract "Objective To investigate the effects of etoposide(VP16)on normal ovary.Methods 40 Young(3-4 months)female SD rats were randomly divided into four groups(10 rats in each group):the control group,low dose VP16 group,middle dose VP16 group and high dose VP16 group.The ovary weight and histomorphological features were observed.Radioimmunoassay was used to analyze blood level of follicle-stimulating hormone(FSH)and estradiol(E2)among the four groups.Immunohistochemistry was used to analyze the expression of caspases-3 protein.Results:The total number of follicle showed a significant reduction in middle close VP16 group and high dose VP16 group,and the level of blood FSH raised abnormally while the level of blood E2 fell.There was no significant reduction of follicle in lower dose VP16 group compared with the control group,and so did the same in the level of FSH and E2.The expression of caspases-3 protein in high dose VP16 group and middle dose VP16 group was significantly higher than the control group and low dose VP16 group.Conclusions:Ovarian damage of VP16 was positive correlated to the change of dose,and apoptosis of ovary might relate to caspases-3 protein in the ovary." @default.
- W2394396254 created "2016-06-24" @default.
- W2394396254 creator A5055066491 @default.
- W2394396254 date "2008-01-01" @default.
- W2394396254 modified "2023-09-23" @default.
- W2394396254 title "Empirical Study on the Damage of Ovary Tissues and Endocrine Secretion in Rat by VP16." @default.
- W2394396254 hasPublicationYear "2008" @default.
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