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- W2394397411 abstract "[Objective] To assess the relationship aming tandem repeats (VNTR) and G894T polymorphisms of the endothelial nitric oxide synthase (eNOS) gene CHD in Henan Han population. [Methods] A total of 207 CHD patients and 264 healthy volunteers were recruited in this case-control study. 27 bp VNTR and G894T polymorphisms of the endothelial nitric oxide synthase gene were detected by PCR-RFLP. Compared genotype frequency and allele gene frequency between CHD group and control group. Haplotype was also analyzed. [Results] There were significant differences in the genotype frequencies of 4a/4a and allele gene frequencies of 4a, and 894T between CHD group and control group (P 0.05). Haplotype analysis revealed that 4a-G, 4b-G had significant differences between CHD group and control group (P 0.05). [Conclusions] The allele gene of 4a and 894T in eNOS gene are associated with CHD and might be the risk factors of CHD for persons carrying it in Henan Han population. The haplotype of 4a-G may increase the risk of CHD, and the haplotype of 4b-G has protective effect against CHD in Henan han population." @default.
- W2394397411 created "2016-06-24" @default.
- W2394397411 creator A5064369996 @default.
- W2394397411 date "2008-01-01" @default.
- W2394397411 modified "2023-09-24" @default.
- W2394397411 title "Research on correlativity of 27 bpVNTR and G894T polymorphisms of endothelial nitric oxide synthase gene and coronary heart disease in Henan Han population" @default.
- W2394397411 hasPublicationYear "2008" @default.
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