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- W2394407945 abstract "Objective:To study the immunologic mechanism of Bushen Yiqi (BSYQ) herbs in protecting bromocriptine induced abortion in rats.Methods:Sixty-one SD rats were randomly divided into 5 groups:Group A:treated with BSYQ herbs for 12 days from the day of vaginal plug observed,and injected with bromocriptine 0.125mg/d subcutaneously (sc) during day 6-8 of pregnancy;group B:in- jected with bromocriptine during the day 6—8 of pregnancy;group C:rats injected with bromocriptin 31ul/d sc at day 6-8 of preg- nancy;group D:rats injected with distilled water for 12 days from the day of vaginal plug observed;group E:non-pregnant rats without any treatment.At day 12 of pregnancy,uterus was taken out for determining embryo and the expression of Th1/Th2 type cytokine in decidua was determined by semiquantitative RT-PCR.Results:Abortion rate;group A vs B was 27 % (4/15) vs 75% (9/12);embryo number:A vs B was 114 vs 25,P0.01.No abortion was found in group C and D.The transcription levels of IL- 4 and IL-10 in group A were higher than that of group B (22.21±2.42 ng/100μl vs 64.81±3.07 ng/100μl;22.40±2.50 ng/ 100μl vs 46.56±3.83 ng/100μl) with significant difference (P0.05).The mean level of TNF-α of A and B were 27.52±6.16 ng/100μl vs 51.19±3.56 ng/100μl,and that of IFN-7 were 17.20±1.13 ng/100μl vs 21.54±2.16 ng/100μl respectively.There was insignificant difference between them (P0.05).Conclusion:A predominant Th1 response at maternal-fetal interface is harm- ful to pregnancy.BSYQ herbs can reverse the abortion effect of bromocriptine through cytokine balance of Th1/Th2 type in decidua to maintain the pregnancy." @default.
- W2394407945 created "2016-06-24" @default.
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- W2394407945 date "2003-01-01" @default.
- W2394407945 modified "2023-09-23" @default.
- W2394407945 title "Effect of Bushen Yiqi Herbs on Th1/Th2 Type Cytokine on Decidua in Bromocriptine Induced Abortion Rats" @default.
- W2394407945 hasPublicationYear "2003" @default.
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