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- W2394410956 abstract "Objective To investigate the effects of LY294002,a specific inhibitor of phosphatidylinositol 3-kinase,on the growth,proliferation,apoptosis,migration and invasion ofgastric cancer cell lines.Methods The growth and proliferation of AGS cells treated with different concentrations of LY294002 were measured by MTT assay.Cell cycle and apoptosis rate of AGS cells were analyzed by flow cytometry (FCM).The ability of cells' invasion and migration were evaluated by would healing and Transwell invasion assay.Results After being cultured with LY294002,the growth of AGS cells was significantly inhibited in dose and time dependent manner (P0.05).Flow cytometry displayed that LY294002 was able to raise AGS cells' apoptosis and induce G1 phase arrest in dose dependence(P0.05).Would healing and Transwell invasion assay showed that the ability of cells' migration and invasion were inhibited.Conclusion LY294002 can significantly inhibit the growth and proliferation of AGS cells in a dose-and-time dependent manner,and its mechanisms may arrest cell cycle and induce apoptosis;LY294002 can inhibit the migration and invasion of AGS cells." @default.
- W2394410956 created "2016-06-24" @default.
- W2394410956 creator A5057883663 @default.
- W2394410956 date "2010-01-01" @default.
- W2394410956 modified "2023-09-25" @default.
- W2394410956 title "Effect of LY294002 on the Proliferation and Invasion of Gastric Cancer Cell Lines" @default.
- W2394410956 hasPublicationYear "2010" @default.
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