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- W2394412796 abstract "Objective To evaluate the efficacy and safety of adefovir dipivoxil(ADV) in the treatment of symptomatic hepatitis B cirrhosis.Mechods Patients who met the criteria were randomized into adefovir dipivoxil group or control group.Both groups received ordinary liver protection drugs while patients in ADV group took additional 10 mg of ADV once a day during 6 monthes.Some laboratory examinations such as ALT,AST,HBV-DNA and Child-Pugh score were observed at the begining and the end of the test respectively.Results At the end of the test,the average levels for the ADV group were as the follows:TBIL 35.2±15.1,ALB 34.6±7.1,ALT 49.2±20.6,AST56.2±23.6,PTA 46.2±9.8,Child-Pugh score 5.9±1.7;the control group:TBIL 59.2±22.5,ALB 31.2±5.9,ALT 88.4±31.6,AST 84.7±27.9,PTA 38.1±8.1,Child-Pugh score 8.2±2.1,The results between the control group and experiment group had significant differences(P0.01).The clearance rates of HBV DNA in ADV group were 52.38%(22/24)and in control group were 16.67%(6/26),which had significant differences(P0.01).The clearance rates of HBeAg in ADV group were 11.9%(5/42)and in control group were 8.33%(3/36),which had no significant differences(P0.05).This might have something to do with the shorter test period.There was one case of the HBeAg to HBeAb seraconversion in the ADV group while none in the control group.Conclusion In the study,treatment with 10 mg adefovir dipivoxil daily significantly reduced serum HBV DNA levels,normalized alanine aminotransferase levels and delayed the course of disease.The patients tolerated well and no adverse effects were observed." @default.
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- W2394412796 date "2008-01-01" @default.
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- W2394412796 title "Clinical analysis on adefovir dipivoxil for the treatment of symptomatic hepatitis B cirrhosis" @default.
- W2394412796 hasPublicationYear "2008" @default.
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