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- W2394430581 abstract "The Agr-Gly-Asp(RGD) tripeptide si recognized as an active series of many adhesive proteins, and RGD gafted onto biomaterials can effectively increase endothelial cells (ECs) adhesion, migration and proliferation. In this study, polyethylene terephthalate (PET) were divided into three groups: Non-coated PET, fibronectin-coated PET, RGD-covalent PET. The adhesive strengths of ECs on the PET surfaces were compared under flow condition (8.19dyne/cm~2 for 4h), and the expression of F-actin and talin were detected by laser confocal microscopy to study the shear-resistant mechanism of adherent cells. Results showed ECs retention rates of RGD-grafted and fibronection-coated group were 43.33% and 40.75% respecitvely, which were much higher than that of non-coated group(13.73%). Rsults of laser confcal microscopy showed RTD and fibronectin could promote F-actin rearrangement, stress fiber formation and talin expression, which might be the mechanism of EC shear-resistance." @default.
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- W2394430581 date "2004-01-01" @default.
- W2394430581 modified "2023-09-25" @default.
- W2394430581 title "Study on Fluid Shear Stress Response of Endothelial Cells Attached on Polyethylene Terephthalate Surfaces Covalently with Synthetic RGD Peptides" @default.
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