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• W2394487098 abstract "Stimulated human monocytes/macrophages are a source of interleukin-6 (IL-6), which is a likely mediator involved in immune and inflammatory reactions. The means to control production of IL-6 by these cells could therefore have therapeutic applications. We report here, for lipopolysaccharide (LPS)-stimulated human monocytes in vitro, that the lymphokine, interferon-gamma (IFN-gamma) (100 U/ml), enhanced the level of IL-6 activity, whereas another lymphokine, interleukin-4 (IL-4) (greater than or equal to 0.1 U/ml; greater than or equal to 1.2 x 10(-11) M), suppressed it. The effects of the two lymphokines were manifested at the level of mRNA. The action of the IL-4 was similar to that of the glucocorticoid, dexamethasone, but observed at a lower molar concentration. Such regulation of monocyte IL-6 activity is similar to that found previously for interleukin-1 (IL-1) and tumour necrosis factor-alpha (TNF-alpha) synthesis." @default.
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• W2394487098 date "1990-09-01" @default.
• W2394487098 modified "2023-10-18" @default.
• W2394487098 title "Contrasting effects of interferon-gamma and interleukin-4 on the interleukin-6 activity of stimulated human monocytes." @default.
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• W2394487098 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1384223" @default.
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