Matches in SemOpenAlex for { <https://semopenalex.org/work/W2394508733> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2394508733 endingPage "20" @default.
- W2394508733 startingPage "614" @default.
- W2394508733 abstract "To estimate the influence of long-term treatment with noradrenergic and serotonergic reuptake inhibitors on activity of pituitary-adrenocortical and sympatho-adrenomedullar systems in animals, we compared the effects of maprotiline (a selective inhibitor of noradrenaline reuptake) and fluxilan (a selective inhibitor of serotonin reuptake) on plasma noradrenaline (NA), adrenaline (A), adrenocorticotropic hormone (ACTH) and corticosterone (CORT) levels in unstressed control and rats exposed to chronic unpredictable mild stress (CUMS).Plasma NA and A were assayed by a radioenzymatic method. Plasma CORT was measured using RIA kits and plasma ACTH by a chemiluminescent method.CUMS did not affect blood plasma NA, A and ACTH content, but elevated plasma CORT level. Maprotiline elevated plasma NA content both in unstressed control and CUMS group, whereas plasma A remained unchanged. Fluxilan acted significantly increasing plasma NA and A concentrations both in control and CUMS rats. Neither maprotiline nor fluxilan affected plasma ACTH level both in unstressed control and CUMS animals. Plasma CORT level in unstressed control rats remained unchanged after maprotiline and fluxilan treatment, while being significantly decreased in CUMS rats.Chronic treatment of adult rat males with maprotiline, a noradrenaline reuptake inhibitor activated sympathoneural system. On the other hand, fluxilan, a serotonin reuptake inhibitor activated both sympathoneural and adrenomedullar system, whereas both antidepressants desensitized HPA axis. The findings described here suggest that elevated plasma catecholamines my contribute to adverse effects of these drugs on cardiovascular parameters during antidepressant therapy." @default.
- W2394508733 created "2016-06-24" @default.
- W2394508733 creator A5012795640 @default.
- W2394508733 creator A5043296031 @default.
- W2394508733 creator A5068670291 @default.
- W2394508733 creator A5080645464 @default.
- W2394508733 date "2007-10-01" @default.
- W2394508733 modified "2023-09-22" @default.
- W2394508733 title "Effects of noradrenaline and serotonin reuptake inhibitors on pituitary-adrenocortical and sympatho-adrenomedullar system of adult rats." @default.
- W2394508733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17984940" @default.
- W2394508733 hasPublicationYear "2007" @default.
- W2394508733 type Work @default.
- W2394508733 sameAs 2394508733 @default.
- W2394508733 citedByCount "5" @default.
- W2394508733 countsByYear W23945087332012 @default.
- W2394508733 crossrefType "journal-article" @default.
- W2394508733 hasAuthorship W2394508733A5012795640 @default.
- W2394508733 hasAuthorship W2394508733A5043296031 @default.
- W2394508733 hasAuthorship W2394508733A5068670291 @default.
- W2394508733 hasAuthorship W2394508733A5080645464 @default.
- W2394508733 hasConcept C126322002 @default.
- W2394508733 hasConcept C134018914 @default.
- W2394508733 hasConcept C170493617 @default.
- W2394508733 hasConcept C185592680 @default.
- W2394508733 hasConcept C2775864247 @default.
- W2394508733 hasConcept C2778514916 @default.
- W2394508733 hasConcept C2779177272 @default.
- W2394508733 hasConcept C2780092697 @default.
- W2394508733 hasConcept C2780352252 @default.
- W2394508733 hasConcept C2780546910 @default.
- W2394508733 hasConcept C2780756443 @default.
- W2394508733 hasConcept C2781161787 @default.
- W2394508733 hasConcept C31487548 @default.
- W2394508733 hasConcept C37000724 @default.
- W2394508733 hasConcept C513476851 @default.
- W2394508733 hasConcept C71315377 @default.
- W2394508733 hasConcept C71924100 @default.
- W2394508733 hasConcept C99631742 @default.
- W2394508733 hasConceptScore W2394508733C126322002 @default.
- W2394508733 hasConceptScore W2394508733C134018914 @default.
- W2394508733 hasConceptScore W2394508733C170493617 @default.
- W2394508733 hasConceptScore W2394508733C185592680 @default.
- W2394508733 hasConceptScore W2394508733C2775864247 @default.
- W2394508733 hasConceptScore W2394508733C2778514916 @default.
- W2394508733 hasConceptScore W2394508733C2779177272 @default.
- W2394508733 hasConceptScore W2394508733C2780092697 @default.
- W2394508733 hasConceptScore W2394508733C2780352252 @default.
- W2394508733 hasConceptScore W2394508733C2780546910 @default.
- W2394508733 hasConceptScore W2394508733C2780756443 @default.
- W2394508733 hasConceptScore W2394508733C2781161787 @default.
- W2394508733 hasConceptScore W2394508733C31487548 @default.
- W2394508733 hasConceptScore W2394508733C37000724 @default.
- W2394508733 hasConceptScore W2394508733C513476851 @default.
- W2394508733 hasConceptScore W2394508733C71315377 @default.
- W2394508733 hasConceptScore W2394508733C71924100 @default.
- W2394508733 hasConceptScore W2394508733C99631742 @default.
- W2394508733 hasIssue "5" @default.
- W2394508733 hasLocation W23945087331 @default.
- W2394508733 hasOpenAccess W2394508733 @default.
- W2394508733 hasPrimaryLocation W23945087331 @default.
- W2394508733 hasRelatedWork W1512983241 @default.
- W2394508733 hasRelatedWork W1855394390 @default.
- W2394508733 hasRelatedWork W1914379946 @default.
- W2394508733 hasRelatedWork W1968685057 @default.
- W2394508733 hasRelatedWork W1976932943 @default.
- W2394508733 hasRelatedWork W1979349505 @default.
- W2394508733 hasRelatedWork W2000666467 @default.
- W2394508733 hasRelatedWork W2014440984 @default.
- W2394508733 hasRelatedWork W2020408639 @default.
- W2394508733 hasRelatedWork W2032854481 @default.
- W2394508733 hasRelatedWork W2039091253 @default.
- W2394508733 hasRelatedWork W2050618259 @default.
- W2394508733 hasRelatedWork W2064594464 @default.
- W2394508733 hasRelatedWork W2088475956 @default.
- W2394508733 hasRelatedWork W2089579499 @default.
- W2394508733 hasRelatedWork W2092496088 @default.
- W2394508733 hasRelatedWork W2111751702 @default.
- W2394508733 hasRelatedWork W2224742922 @default.
- W2394508733 hasRelatedWork W2278542502 @default.
- W2394508733 hasRelatedWork W2414534888 @default.
- W2394508733 hasVolume "28" @default.
- W2394508733 isParatext "false" @default.
- W2394508733 isRetracted "false" @default.
- W2394508733 magId "2394508733" @default.
- W2394508733 workType "article" @default.