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- W2394574230 abstract "Ca2+ channel blocker verapamil (0.2 mM) and K+ channel blocker 2-aminopyridine (1.0 mM; 5.0 mM and 10.0 mM) have been studied for their effect on ACTH-stimulated steroidogenesis in isolated adrenal glands (IAG) of the adult (6-7 months) and old (26-28 months) male rats. The administration of verapamil produced a similar, about 2-fold decrease in ACTH-stimulated secretion of 11-OCS in the IAG of both animal groups. 2-aminopyridine, administered in several concentrations, produced no effect whatsoever on ACTH-stimulated secretion of 11-OCS in the IAG of the old rats. However, when administered in concentrations of 5.0 mM and 10.0 mM this agent decreased significantly the ACTH-stimulated steroidogenesis in the IAG of the adult animals. It has been suggested that plasma membrane permeability of z. fasciculata adrenocorticocytes to K+ ions decreases with age." @default.
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- W2394574230 date "1990-09-01" @default.
- W2394574230 modified "2023-09-24" @default.
- W2394574230 title "[Effect of Ca2+- and K+-channel blockers on ACTH-stimulated steroidogenesis of isolated adrenal glands of adult and old rats]." @default.
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