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• W2394711339 abstract "Internalization of gap junction plaques results in the formation of annular gap junction vesicles. The factors that regulate the coordinated internalization of the gap junction plaques to form annular gap junction vesicles, and the subsequent events involved in annular gap junction processing have only relatively recently been investigated in detail. However it is becoming clear that while annular gap junction vesicles have been demonstrated to be degraded by autophagosomal and endo-lysosomal pathways, they undergo a number of additional processing events. Here, we characterize the morphology of the annular gap junction vesicle and review the current knowledge of the processes involved in their formation, fission, fusion, and degradation. In addition, we address the possibility for connexin protein recycling back to the plasma membrane to contribute to gap junction formation and intercellular communication. Information on gap junction plaque removal from the plasma membrane and the subsequent processing of annular gap junction vesicles is critical to our understanding of cell-cell communication as it relates to events regulating development, cell homeostasis, unstable proliferation of cancer cells, wound healing, changes in the ischemic heart, and many other physiological and pathological cellular phenomena." @default.
• W2394711339 created "2016-06-24" @default.
• W2394711339 creator A5021702128 @default.
• W2394711339 creator A5058904025 @default.
• W2394711339 creator A5068759792 @default.
• W2394711339 creator A5091165587 @default.
• W2394711339 date "2016-05-24" @default.
• W2394711339 modified "2023-10-14" @default.
• W2394711339 title "Molecular mechanisms regulating formation, trafficking and processing of annular gap junctions" @default.
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