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- W2394787128 abstract "Studies of the irregular and transient in vitro cytopathic effect of feline panleucopaenia virus have shown that the transiency of cellular destruction is due to a selective and specific affinity of the virus for cells in active mitosis. As cells reach the resting stage of a full tissue culture monolayer, they become resistant to virus action, and this fact, coupled with the presence of widespread heat stable virus inhibitors in sera used to supplement media, is the cause of variability of in vitro cytopathic effect. By injecting cells during the young, actively mitotic phase, and using non-inhibitory sera, good reproducible results may be obtained. By the application of such techniques in vitro, it was possible to obtain a growth curve for the virus, the major features of which are presented. The significance to pathogenicity of a virus with this particular tropism for actively dividing cells is discussed." @default.
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- W2394787128 date "1967-04-01" @default.
- W2394787128 modified "2023-09-26" @default.
- W2394787128 title "Feline Panleucopaenia Virus" @default.
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- W2394787128 doi "https://doi.org/10.1016/s0034-5288(18)34643-5" @default.
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