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• W2394815559 abstract "Purpose: This study was undertaken to reveal the molecular mechanism underlying sulindac-induced apoptosis in the human colon cancer cell line HT-29 (mutant p53). Methods: Apoptosis was determined by using Hoechst 33342 staining, and translocation of proteins was established by using immunofluorescence, immunoelectron microscopy, and Western blotting after ultra- fractionation. Results: This type of apoptosis was associated with decreased mitochondrial membrane potential, a translocation of the apoptosis-inducing factor (AIF) to the nucleus, and morphological evidence of nuclear condensation. However, DNA electrophoresis did not elucidate the ladder pattern of DNA fragments. Instead, a pulse-field gel electrophoresis showed that sulindac led to disintegration of nuclear DNA into-highmolecular-weight DNA fragments of about 100-300 kbp. Conclusions: Our findings indicate that sulindac induces large-scale DNA fragmentation, suggesting a predominantly AIF-mediated cell-death process, through translocation of the AIF to the nucleus in HT-29 cells." @default.
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• W2394815559 date "2004-01-01" @default.
• W2394815559 modified "2023-09-22" @default.
• W2394815559 title "Sulindac-induced Apoptosis without Oligonucleosomal DNA Fragmentation in HT-29 Cells - Its Special References to Mitochondrial Pathway -" @default.
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