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• W2394820908 abstract "Objectives: The objective of this study is to evaluate the potential usefulness of middle cerebral artery peak systolic velocity (MCA-PSV) as a non-invasive means of detecting an anemic fetus from homozygous alphathalassemia-1 Material and Method : We observed four cases of referrals with complicated pregnancies in which the fetuses were suspected with homozygous alpha-thalassemia-1. Three out of four cases involved hydrop fetalis, detected through previous ultrasounds, while the remaining case was referred for prenatal diagnosis. Subsequently, we performed a detailed ultrasound and fetal MCA-PSV in all cases, and to confirm the diagnosis, we also performed cordocentesis. Results: With all the four cases having the gestational age range from 18 to 27 weeks, three showed hydrop fetalis. The remaining case, the 18-week gestational age fetus referred for prenatal diagnosis, showed an increase in the cardiothoracic ratio without other signs of hydrop fetalis. MCA-PSV suggested the presence of fetal anemia in all cases (with the velocity ranging from 37.3 to 62.2 cm/sec). The results obtained from cordocentesis confirmed fetal anemia and homozygous alpha-thalassemia-1 in all cases. Conclusion: Peak systolic velocity of fetal middle cerebral artery can predict anemia in fetus affected with homozygous alpha-thalassemia-1 disease. Keywords: Thalassemia, Hydrops, Middle cerebral artery peak systolic flow, Fetal anemia" @default.
• W2394820908 created "2016-06-24" @default.
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• W2394820908 date "2010-02-01" @default.
• W2394820908 modified "2023-09-24" @default.
• W2394820908 title "Middle cerebral artery peak systolic velocity in fetuses with homozygous alpha-thalassemia-1: case series." @default.
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• W2394820908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21302404" @default.
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