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- W239482825 abstract "This chapter provides a broad view of urinary tract cancer, ranging from the prognostic importance of histopathological changes in clinical practice to a consideration of the significance of molecular structure in the mode of action of carcinogens. Interest in bladder cancer has been greatly heightened by the knowledge that a small proportion of the disease in man results from the accidental exposure to a few specific chemicals such as 2-naphthylamine. As far as is known, this exposure occurs during work in a restricted group of industries that either make or use these carcinogens. This success has stimulated research in two directions—the design of experimental models for the laboratory investigation of bladder cancer and the study of the carcinogenic activity in the bladder epithelium of environmentally important substances such as potential new drugs, pesticides, and food additives. Electron-microscopic examination of the luminal surface of the bladder, either by the replica technique or by scanning electron microscopy, has shown that the large, polygonal cells are arranged in a fairly regular pattern, having somewhat irregular surfaces and slightly upturned lips along their contact margins. The main advancement in the understanding of the physiology of bladder epithelium has come from the study of the passage of radioactive-labeled tracers across the bladder epithelium under a variety of conditions, both in vivo and in vitro. In man, clinical observations have shown that the healing of bladder wounds is rapid, and relatively large areas of the bladder can be re-epithelialized following the stripping of the epithelium." @default.
- W239482825 created "2016-06-24" @default.
- W239482825 creator A5020586556 @default.
- W239482825 creator A5061070333 @default.
- W239482825 date "1970-01-01" @default.
- W239482825 modified "2023-10-06" @default.
- W239482825 title "Cancer Of The Urinary Tract" @default.
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