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- W2394837408 abstract "Objective To assess the value of Aspergillus galactomannan (GM) double-direct sandwich enzyme-linked immunosorbent assay (ELISA) in the diagnosis of invasive aspergillosis (IA). Methods Forty nine patients were divided into IA group (n = 11), other invasive fungal infection group (n = 20) and Aspergillus colonization group (n = 18). The serum samples of all patients and 6 patients with IA after 7 day treatment were used for GM detection. A double-direct sandwich ELISA was employed to detect GM optical density index (ODI) in the serum samples. Measurement data followed the Gaussian distribution were expressed as x +/- s. Differences among groups were tested using a one factor analysis of variance. The significance of variation before and after therapy was tested with paired t test. P Results The serum GM ODI in IA patients was higher (1.63 +/- 0.29) than that in other IFI patients (0.96 +/- 0.49) and Aspergillus colonization patients (0.83 +/- 0.43) , F = 12.681, P 0.05), respectively. If the cutoff GM ODI was 1.5, the sensitivity, specificity, positive predictive value and negative predictive value for diagnosis of IA in the patients were 72.7% , 84.2%, 57.1% and 94.1%, respectively. Conclusions The serum GM detection has diagnostic value for IA and could distinguish Aspergillus infection from other invasive fungal infections and Aspergillus colonization. A cutoff GM ODI of 1.5 showed the best sensitivity and specificity for IA in the patients." @default.
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- W2394837408 date "2008-04-01" @default.
- W2394837408 modified "2023-09-24" @default.
- W2394837408 title "Evaluation of the galactomannan assay for the diagnosis of invasive aspergillosis in patients" @default.
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