Matches in SemOpenAlex for { <https://semopenalex.org/work/W2394863193> ?p ?o ?g. }
- W2394863193 endingPage "29" @default.
- W2394863193 startingPage "22" @default.
- W2394863193 abstract "The aim of this paper is to develop a minimal model describing events leading to the onset of Parkinson's disease (PD). The model accounts for α-synuclein (α-syn) production in the soma, transport toward the synapse, misfolding, and aggregation. The production and aggregation of polymeric α-syn is simulated using a minimalistic 2-step Finke–Watzky model. We utilized the developed model to analyze what changes in a healthy neuron are likely to lead to the onset of α-syn aggregation. We checked the effects of interruption of α-syn transport toward the synapse, entry of misfolded (infectious) α-syn into the somatic and synaptic compartments, increasing the rate of α-syn synthesis in the soma, and failure of α-syn degradation machinery. Our model suggests that failure of α-syn degradation machinery is probably the most likely cause for the onset of α-syn aggregation leading to PD." @default.
- W2394863193 created "2016-06-24" @default.
- W2394863193 creator A5008465009 @default.
- W2394863193 creator A5075453637 @default.
- W2394863193 date "2016-08-01" @default.
- W2394863193 modified "2023-10-14" @default.
- W2394863193 title "What can trigger the onset of Parkinson's disease – A modeling study based on a compartmental model of α-synuclein transport and aggregation in neurons" @default.
- W2394863193 cites W1514640482 @default.
- W2394863193 cites W1630502818 @default.
- W2394863193 cites W1779507217 @default.
- W2394863193 cites W1851334881 @default.
- W2394863193 cites W1897859562 @default.
- W2394863193 cites W1901504596 @default.
- W2394863193 cites W1972559442 @default.
- W2394863193 cites W1973319971 @default.
- W2394863193 cites W1978989017 @default.
- W2394863193 cites W1979448745 @default.
- W2394863193 cites W1979591162 @default.
- W2394863193 cites W1984156308 @default.
- W2394863193 cites W1989732798 @default.
- W2394863193 cites W1992548377 @default.
- W2394863193 cites W1993428001 @default.
- W2394863193 cites W1996155374 @default.
- W2394863193 cites W2004121740 @default.
- W2394863193 cites W2012983695 @default.
- W2394863193 cites W2017642230 @default.
- W2394863193 cites W2027649342 @default.
- W2394863193 cites W2028955297 @default.
- W2394863193 cites W2030187848 @default.
- W2394863193 cites W2031978571 @default.
- W2394863193 cites W2033827101 @default.
- W2394863193 cites W2054868321 @default.
- W2394863193 cites W2060776482 @default.
- W2394863193 cites W2064820671 @default.
- W2394863193 cites W2075997185 @default.
- W2394863193 cites W2078955175 @default.
- W2394863193 cites W2080148133 @default.
- W2394863193 cites W2086850124 @default.
- W2394863193 cites W2106179404 @default.
- W2394863193 cites W2118221606 @default.
- W2394863193 cites W2122566696 @default.
- W2394863193 cites W2127649583 @default.
- W2394863193 cites W2128821570 @default.
- W2394863193 cites W2145653859 @default.
- W2394863193 cites W2146706912 @default.
- W2394863193 cites W2156179625 @default.
- W2394863193 cites W2167493580 @default.
- W2394863193 doi "https://doi.org/10.1016/j.mbs.2016.05.002" @default.
- W2394863193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27211070" @default.
- W2394863193 hasPublicationYear "2016" @default.
- W2394863193 type Work @default.
- W2394863193 sameAs 2394863193 @default.
- W2394863193 citedByCount "18" @default.
- W2394863193 countsByYear W23948631932017 @default.
- W2394863193 countsByYear W23948631932018 @default.
- W2394863193 countsByYear W23948631932019 @default.
- W2394863193 countsByYear W23948631932020 @default.
- W2394863193 countsByYear W23948631932021 @default.
- W2394863193 countsByYear W23948631932022 @default.
- W2394863193 countsByYear W23948631932023 @default.
- W2394863193 crossrefType "journal-article" @default.
- W2394863193 hasAuthorship W2394863193A5008465009 @default.
- W2394863193 hasAuthorship W2394863193A5075453637 @default.
- W2394863193 hasConcept C127445978 @default.
- W2394863193 hasConcept C136238340 @default.
- W2394863193 hasConcept C142724271 @default.
- W2394863193 hasConcept C169760540 @default.
- W2394863193 hasConcept C185592680 @default.
- W2394863193 hasConcept C2778794669 @default.
- W2394863193 hasConcept C2779134260 @default.
- W2394863193 hasConcept C2779617337 @default.
- W2394863193 hasConcept C2779734285 @default.
- W2394863193 hasConcept C71924100 @default.
- W2394863193 hasConcept C86803240 @default.
- W2394863193 hasConcept C95444343 @default.
- W2394863193 hasConceptScore W2394863193C127445978 @default.
- W2394863193 hasConceptScore W2394863193C136238340 @default.
- W2394863193 hasConceptScore W2394863193C142724271 @default.
- W2394863193 hasConceptScore W2394863193C169760540 @default.
- W2394863193 hasConceptScore W2394863193C185592680 @default.
- W2394863193 hasConceptScore W2394863193C2778794669 @default.
- W2394863193 hasConceptScore W2394863193C2779134260 @default.
- W2394863193 hasConceptScore W2394863193C2779617337 @default.
- W2394863193 hasConceptScore W2394863193C2779734285 @default.
- W2394863193 hasConceptScore W2394863193C71924100 @default.
- W2394863193 hasConceptScore W2394863193C86803240 @default.
- W2394863193 hasConceptScore W2394863193C95444343 @default.
- W2394863193 hasLocation W23948631931 @default.
- W2394863193 hasLocation W23948631932 @default.
- W2394863193 hasOpenAccess W2394863193 @default.
- W2394863193 hasPrimaryLocation W23948631931 @default.
- W2394863193 hasRelatedWork W1180809072 @default.
- W2394863193 hasRelatedWork W1968763225 @default.
- W2394863193 hasRelatedWork W2005273706 @default.
- W2394863193 hasRelatedWork W2018243751 @default.
- W2394863193 hasRelatedWork W2033189714 @default.
- W2394863193 hasRelatedWork W2040277507 @default.
- W2394863193 hasRelatedWork W2127126535 @default.