Matches in SemOpenAlex for { <https://semopenalex.org/work/W2394886175> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2394886175 endingPage "S25" @default.
- W2394886175 startingPage "S22" @default.
- W2394886175 abstract "The pharmacology and clinical efficacy of cholinesterase inhibitors (ChEIs) in patients with Alzheimer's disease (AD) are discussed. ChEIs can be classified pharmacologically on the basis of the duration of cholinesterase inhibition. The duration of inhibition is short for tacrine and donepezil, intermediate for rivastigmine, and long for metrifonate. Pharmacokinetic differences also distinguish ChEIs. The two instruments that are most accepted for use in evaluating the efficacy of drugs for AD are the Alzheimer's Disease Assessment Scale-Cognitive Portion (ADAS-Cog) and the Clinician's Interview-Based Impression of Change with Caregiver Input (CIBIC-Plus). In clinical trials, all ChEIs have produced improvements in the cognitive deficits seen in patients with AD, and some have also improved behavioral problems and increased patients' ability to perform activities of daily living. Only donepezil and metrifonate are administered once daily. Except for metrifonate, the dosage of each drug should be adjusted upward over several weeks to minimize adverse effects. Hepatotoxicity, the most important adverse effect of tacrine, has not been observed with other ChEIs. Tacrine and donepezil have the potential to interact with other drugs that depend on the same metabolic pathways. Although ChEIs generally improve cognition in patients with AD, differences among these medications are substantial in some cases and should be thoroughly considered by clinicians." @default.
- W2394886175 created "2016-06-24" @default.
- W2394886175 creator A5052922966 @default.
- W2394886175 date "1998-11-01" @default.
- W2394886175 modified "2023-10-18" @default.
- W2394886175 title "Pharmacology and clinical efficacy of cholinesterase inhibitors" @default.
- W2394886175 doi "https://doi.org/10.1093/ajhp/55.suppl_2.s22" @default.
- W2394886175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9809108" @default.
- W2394886175 hasPublicationYear "1998" @default.
- W2394886175 type Work @default.
- W2394886175 sameAs 2394886175 @default.
- W2394886175 citedByCount "16" @default.
- W2394886175 countsByYear W23948861752016 @default.
- W2394886175 countsByYear W23948861752019 @default.
- W2394886175 countsByYear W23948861752022 @default.
- W2394886175 crossrefType "journal-article" @default.
- W2394886175 hasAuthorship W2394886175A5052922966 @default.
- W2394886175 hasBestOaLocation W23948861751 @default.
- W2394886175 hasConcept C126322002 @default.
- W2394886175 hasConcept C181199279 @default.
- W2394886175 hasConcept C185592680 @default.
- W2394886175 hasConcept C197934379 @default.
- W2394886175 hasConcept C2776332859 @default.
- W2394886175 hasConcept C2778816929 @default.
- W2394886175 hasConcept C2779046751 @default.
- W2394886175 hasConcept C2779056891 @default.
- W2394886175 hasConcept C2779134260 @default.
- W2394886175 hasConcept C2779483572 @default.
- W2394886175 hasConcept C2780904820 @default.
- W2394886175 hasConcept C31896038 @default.
- W2394886175 hasConcept C502032728 @default.
- W2394886175 hasConcept C535046627 @default.
- W2394886175 hasConcept C55493867 @default.
- W2394886175 hasConcept C71924100 @default.
- W2394886175 hasConcept C98274493 @default.
- W2394886175 hasConceptScore W2394886175C126322002 @default.
- W2394886175 hasConceptScore W2394886175C181199279 @default.
- W2394886175 hasConceptScore W2394886175C185592680 @default.
- W2394886175 hasConceptScore W2394886175C197934379 @default.
- W2394886175 hasConceptScore W2394886175C2776332859 @default.
- W2394886175 hasConceptScore W2394886175C2778816929 @default.
- W2394886175 hasConceptScore W2394886175C2779046751 @default.
- W2394886175 hasConceptScore W2394886175C2779056891 @default.
- W2394886175 hasConceptScore W2394886175C2779134260 @default.
- W2394886175 hasConceptScore W2394886175C2779483572 @default.
- W2394886175 hasConceptScore W2394886175C2780904820 @default.
- W2394886175 hasConceptScore W2394886175C31896038 @default.
- W2394886175 hasConceptScore W2394886175C502032728 @default.
- W2394886175 hasConceptScore W2394886175C535046627 @default.
- W2394886175 hasConceptScore W2394886175C55493867 @default.
- W2394886175 hasConceptScore W2394886175C71924100 @default.
- W2394886175 hasConceptScore W2394886175C98274493 @default.
- W2394886175 hasIssue "suppl_2" @default.
- W2394886175 hasLocation W23948861751 @default.
- W2394886175 hasLocation W23948861752 @default.
- W2394886175 hasOpenAccess W2394886175 @default.
- W2394886175 hasPrimaryLocation W23948861751 @default.
- W2394886175 hasRelatedWork W1996956475 @default.
- W2394886175 hasRelatedWork W2016149437 @default.
- W2394886175 hasRelatedWork W2017645489 @default.
- W2394886175 hasRelatedWork W2037986700 @default.
- W2394886175 hasRelatedWork W2063268875 @default.
- W2394886175 hasRelatedWork W2086916510 @default.
- W2394886175 hasRelatedWork W2089223747 @default.
- W2394886175 hasRelatedWork W2980147368 @default.
- W2394886175 hasRelatedWork W4249581208 @default.
- W2394886175 hasRelatedWork W76608054 @default.
- W2394886175 hasVolume "55" @default.
- W2394886175 isParatext "false" @default.
- W2394886175 isRetracted "false" @default.
- W2394886175 magId "2394886175" @default.
- W2394886175 workType "article" @default.