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- W2394893239 abstract "Recent literature has reported increased thromboembolic events in patients with dilated cardiomyopathy. In particular, a study by Fuster et al. described an incidence of 18%. Recent analyses of larger studies such as the Vasodilators in Heart Failure (V-HeFT) study and Studies of Left Ventricular Dysfunction (SOLVD) have shown rates of 2.7/100 patient years and 2.4/100 patient years respectively. For the dilated cardiOMVODathy population, there is an increased risk of developing an intracardiac thrombus secondary to stasis of blood. These thrombi are thought to predispose to thromboembolic events such as stroke and peripheral artery occlusion. In clinical practice, a majority of patients with intracardiac thrombi are anticoagulated with systemic agents such as heparin or cournadin to prevent such events. However, studies regarding the effectiveness of this clinical practice have not been conclusive. A study by Gottdiener et al. showed no significant increase in systemic emboli in patients with a known left ventricular thrombus. On the other hand, while other studies such as those by Katz et al and Falk et al. showed an increased incidence of embolic events in patient with a thrombus, the patient populations were too small to draw solid conclusions. Furthermore, these studies also failed to investigate the effectiveness of anticoagulation. A recent attempt at a retrospective analysis by Sharma et al likewise had too few patients to draw significant conclusions. The purpose of this study is to investigate the incidence of thromboembolic events in patients with dilated cardiomyopathy and a left ventricular thrombus. Furthermore, we will attempt to identify risk factors for embolic events and the protective role of anticoagulation and/or aspirin and/or clopidogrel therapy. Because ColumbiaPresbyterian Medical Center is a tertiary referral center for patients with heart failure, we expect to have records on a significantly larger population than previously studied. B. Study Design and Statistical Analysis" @default.
- W2394893239 created "2016-06-24" @default.
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- W2394893239 date "2001-01-01" @default.
- W2394893239 modified "2023-09-26" @default.
- W2394893239 title "Left Ventricular Thrombus and Dilated Cardiomyopathy: Role of Anticoagulation in Prevention of Thromboembolic Events" @default.
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