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- W2394920338 abstract "To clarify the localization of alkaline phosphatase (Al-Pase) during the development of the mouse submandibular and sublingual glands, histological and histochemical time course observations were made from the 16 th day of fetal life to the 12 th postnatal week. On the 16 th day of fetal life when the epithelial terminal cells still showed the end buds, Al-Pase activity was detected on every cytoplasmic membrane except the basal membrane side of the end buds. On the 18 th day of fetal life when the terminal tubule began to appear, Al-Pase activity was limited only to the luminal surface membrane of the terminal tubule cells and the activity was negative in the myoepithelial cell precursors. After the 2 nd postnatal week, Al-Pase activity was also observed on the cytoplasmic membrane of the myoepithelial cells around the duct system and the acini, whereas the activity in the luminal surface membrane of the terminal tubule cells declined later on. On the 4 th postnatal week Al-Pase activity was seen only on the cytoplasmic membrane of the myoepithelial cells, but the activity in the luminal surface membrane of the terminal tubule cells had disappeared. These results indicate that two types of Al-Pase, which are comparable to those of the fetal and adult types in rats as pointed out by Fukushima[Tr. Soc. Pathol. Vol. 70 (Supple.), pp.45-64 1981], are also expressed in a successive manner in the mouse salivary gland ontogenesis, as in rats, although there are some differences between mice and rats. During the histochemical study, the author developed a modified fixation-embedding technique to preserve Al-Pase activity as well as fine detail of the histological structure." @default.
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- W2394920338 date "1990-01-01" @default.
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- W2394920338 title "Fetal alkaline phosphatase of mouse salivary glands." @default.
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- W2394920338 doi "https://doi.org/10.2330/joralbiosci1965.32.410" @default.
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