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- W2394947066 abstract "As the large defect of peripheral nerve occurs, the autologous nerve graft is the most ideal method but it has many limitations due to donor site morbidities. Various materials have been developed for the nerve defect as the conduits, but none of these materials is satisfactory. Among them, Gore-Tex tube seems to be one of the most ideal nerve conduit materials at peripheral nerve defect. Many researches have focused on finding the neurotrophic factors. It is recently demonstrated that Valproic acid(VPA) has an effect of axonal regeneration as a neurotrophic factor without enzymatic degradation and toxicity problems. The purpose of this study is to evaluate the effect of VPA on the nerve regeneration at the peripheral nerve defect. A 10mm gap of rat sciatic nerve was made and Gore-Tex tube filled with biceps femoris muscle was placed at the nerve defect site. We let the rat take VPA as drinking water in experimental group and did not give VPA to the control group. We estimated the results as electrophysiologic and histological aspects for 16 weeks after the surgery. The nerve conduction velocity, total myelinated axon count, myelin sheath thickness and mean nerve fiber diameter significantly increased in VPA-treated experimental group when compared to the control (p" @default.
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- W2394947066 date "2006-03-01" @default.
- W2394947066 modified "2023-09-26" @default.
- W2394947066 title "Valproic Acid Effect in Nerve Regeneration Using Gore-Tex(R) Tube Filled with Skeletal Muscle." @default.
- W2394947066 hasPublicationYear "2006" @default.
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