FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2394967319> ?p ?o ?g. }

• W2394967319 endingPage "pyw046" @default.
• W2394967319 startingPage "pyw046" @default.
• W2394967319 abstract "Depression is a serious psychiatric disorder that easily causes physical impairments and a high suicide rate. Monosialotetrahexosylganglioside is a crucial ganglioside for the central nervous system and has been reported to affect the function of the brain derived neurotrophic factor system. This study is aimed to evaluate whether monosialotetrahexosylganglioside has antidepressant-like effects. Antidepressant-like effects of monosialotetrahexosylganglioside were assessed in the chronic social defeat stress model of depression, and various behavioral tests were performed. Changes in the brain derived neurotrophic factor signaling pathway after chronic social defeat stress and monosialotetrahexosylganglioside treatment were also investigated. A tryptophan hydroxylase inhibitor and brain derived neurotrophic factor signaling inhibitors were used to determine the antidepressant mechanisms of monosialotetrahexosylganglioside. Monosialotetrahexosylganglioside administration significantly reversed the chronic social defeat stress-induced reduction of sucrose preference and social interaction in mice and also prevented the increased immobility time in the forced swim test and tail suspension test. In addition, monosialotetrahexosylganglioside completely ameliorated the stress-induced dysfunction of brain derived neurotrophic factor signaling cascade in the hippocampus and medial prefrontal cortex, 2 regions closely involved in the pathophysiology of depression. Furthermore, the usage of brain derived neurotrophic factor signaling cascade inhibitors, K252a and anti-brain derived neurotrophic factor antibody, each abolished the antidepressant-like effects of monosialotetrahexosylganglioside, while the usage of a serotonin system inhibitor did not. Taken together, our findings suggest that monosialotetrahexosylganglioside indeed has antidepressant-like effects, and these effects were mediated through the activation of brain derived neurotrophic factor signaling cascade." @default.
• W2394967319 created "2016-06-24" @default.
• W2394967319 creator A5028813896 @default.
• W2394967319 creator A5030011548 @default.
• W2394967319 creator A5031540971 @default.
• W2394967319 creator A5032868305 @default.
• W2394967319 creator A5064024990 @default.
• W2394967319 creator A5089094244 @default.
• W2394967319 date "2016-05-10" @default.
• W2394967319 modified "2023-10-14" @default.
• W2394967319 title "Antidepressant-Like Effects of GM1 Ganglioside Involving the BDNF Signaling Cascade in Mice" @default.
• W2394967319 cites W1489716577 @default.
• W2394967319 cites W1596652845 @default.
• W2394967319 cites W1815714247 @default.
• W2394967319 cites W1850032865 @default.
• W2394967319 cites W1950744654 @default.
• W2394967319 cites W1963674989 @default.
• W2394967319 cites W1968696128 @default.
• W2394967319 cites W1972936661 @default.
• W2394967319 cites W1977815070 @default.
• W2394967319 cites W1978736409 @default.
• W2394967319 cites W1983295831 @default.
• W2394967319 cites W1988670362 @default.
• W2394967319 cites W1989795214 @default.
• W2394967319 cites W1990963002 @default.
• W2394967319 cites W1993912261 @default.
• W2394967319 cites W1996070098 @default.
• W2394967319 cites W1996555743 @default.
• W2394967319 cites W1999104671 @default.
• W2394967319 cites W2002669733 @default.
• W2394967319 cites W2003982930 @default.
• W2394967319 cites W2005843543 @default.
• W2394967319 cites W2009882594 @default.
• W2394967319 cites W2011192445 @default.
• W2394967319 cites W2014871422 @default.
• W2394967319 cites W2016374423 @default.
• W2394967319 cites W2016956559 @default.
• W2394967319 cites W2025682675 @default.
• W2394967319 cites W2029145502 @default.
• W2394967319 cites W2035555835 @default.
• W2394967319 cites W2036428426 @default.
• W2394967319 cites W2042335899 @default.
• W2394967319 cites W2043727061 @default.
• W2394967319 cites W2047953858 @default.
• W2394967319 cites W2048084192 @default.
• W2394967319 cites W2049599503 @default.
• W2394967319 cites W2050454233 @default.
• W2394967319 cites W2055888903 @default.
• W2394967319 cites W2058117427 @default.
• W2394967319 cites W2062102986 @default.
• W2394967319 cites W2066471688 @default.
• W2394967319 cites W2071857166 @default.
• W2394967319 cites W2072437381 @default.
• W2394967319 cites W2076174474 @default.
• W2394967319 cites W2076866333 @default.
• W2394967319 cites W2082974330 @default.
• W2394967319 cites W2084681734 @default.
• W2394967319 cites W2091194550 @default.
• W2394967319 cites W2091463654 @default.
• W2394967319 cites W2093219983 @default.
• W2394967319 cites W2101101202 @default.
• W2394967319 cites W2110127543 @default.
• W2394967319 cites W2111038577 @default.
• W2394967319 cites W2114770966 @default.
• W2394967319 cites W2117830068 @default.
• W2394967319 cites W2123856483 @default.
• W2394967319 cites W2124826487 @default.
• W2394967319 cites W2130685024 @default.
• W2394967319 cites W2134083528 @default.
• W2394967319 cites W2137385309 @default.
• W2394967319 cites W2140178312 @default.
• W2394967319 cites W2143247032 @default.
• W2394967319 cites W2146890278 @default.
• W2394967319 cites W2146985664 @default.
• W2394967319 cites W2167662696 @default.
• W2394967319 cites W2282636056 @default.
• W2394967319 cites W2337445998 @default.
• W2394967319 cites W2793634050 @default.
• W2394967319 cites W4232356038 @default.
• W2394967319 cites W4242566730 @default.
• W2394967319 cites W4248527470 @default.
• W2394967319 doi "https://doi.org/10.1093/ijnp/pyw046" @default.
• W2394967319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5043648" @default.
• W2394967319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27207911" @default.
• W2394967319 hasPublicationYear "2016" @default.
• W2394967319 type Work @default.
• W2394967319 sameAs 2394967319 @default.
• W2394967319 citedByCount "18" @default.
• W2394967319 countsByYear W23949673192016 @default.
• W2394967319 countsByYear W23949673192017 @default.
• W2394967319 countsByYear W23949673192018 @default.
• W2394967319 countsByYear W23949673192020 @default.
• W2394967319 countsByYear W23949673192021 @default.
• W2394967319 countsByYear W23949673192022 @default.
• W2394967319 countsByYear W23949673192023 @default.
• W2394967319 crossrefType "journal-article" @default.
• W2394967319 hasAuthorship W2394967319A5028813896 @default.
• W2394967319 hasAuthorship W2394967319A5030011548 @default.

• next