FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2394987254> ?p ?o ?g. }

• W2394987254 endingPage "368" @default.
• W2394987254 startingPage "361" @default.
• W2394987254 abstract "Hepatitis E virus (HEV) genotype 3 infections are frequent in Europe and North America, with acute and chronic courses described in the literature. HEV RNA detection by real-time polymerase chain reaction (PCR) is the gold standard for diagnosis. Recently, an anti-HEV antigen (Ag)-specific enzyme-linked immunosorbent assay (ELISA) directed against the HEV capsid became commercially available. The effectiveness of anti-HEV Ag-specific ELISA at detecting HEV genotype 3 infections remains undefined.The performance of anti-HEV Ag-ELISA was compared with that of real-time PCR, using sera from a cohort of acutely infected individuals, in addition to a cohort of chronically infected patients undergoing ribavirin therapy. Furthermore, virion properties were evaluated by density fractionation.Anti-HEV Ag-specific ELISA was less sensitive than real-time PCR at detection of HEV infection. Anti-HEV Ag-specific ELISA revealed significantly higher HEV Ag in chronically infected individuals as compared to acutely infected patients, with high sensitivity and specificity to distinguish acute from chronic HEV infection. Of note, HEV Ag remained detectable for >100 days after HEV RNA clearance in ribavirin-treated patients with chronic HEV. Density gradients revealed the presence of membrane-associated virions in the sera, with a different distribution as compared to HEV RNA.The anti-HEV Ag-specific ELISA is less sensitive than HEV RNA real-time PCR but represents a useful tool to discriminate chronic from acute infection." @default.
• W2394987254 created "2016-06-24" @default.
• W2394987254 creator A5002183557 @default.
• W2394987254 creator A5006866490 @default.
• W2394987254 creator A5019174432 @default.
• W2394987254 creator A5043540405 @default.
• W2394987254 creator A5048573821 @default.
• W2394987254 creator A5050526088 @default.
• W2394987254 creator A5060383367 @default.
• W2394987254 creator A5076739762 @default.
• W2394987254 date "2016-05-27" @default.
• W2394987254 modified "2023-10-15" @default.
• W2394987254 title "Hepatitis E Virus (HEV) ORF2 Antigen Levels Differentiate Between Acute and Chronic HEV Infection" @default.
• W2394987254 cites W1671822578 @default.
• W2394987254 cites W1912852622 @default.
• W2394987254 cites W1947896821 @default.
• W2394987254 cites W1968389980 @default.
• W2394987254 cites W1969251068 @default.
• W2394987254 cites W1985329812 @default.
• W2394987254 cites W1989751941 @default.
• W2394987254 cites W2011506596 @default.
• W2394987254 cites W2012382212 @default.
• W2394987254 cites W2013043016 @default.
• W2394987254 cites W2017876935 @default.
• W2394987254 cites W2058230403 @default.
• W2394987254 cites W2109673851 @default.
• W2394987254 cites W2118422968 @default.
• W2394987254 cites W2142737949 @default.
• W2394987254 cites W2150602209 @default.
• W2394987254 cites W2156915517 @default.
• W2394987254 cites W2160152038 @default.
• W2394987254 cites W2163046433 @default.
• W2394987254 cites W2312406428 @default.
• W2394987254 doi "https://doi.org/10.1093/infdis/jiw161" @default.
• W2394987254 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27234418" @default.
• W2394987254 hasPublicationYear "2016" @default.
• W2394987254 type Work @default.
• W2394987254 sameAs 2394987254 @default.
• W2394987254 citedByCount "47" @default.
• W2394987254 countsByYear W23949872542016 @default.
• W2394987254 countsByYear W23949872542017 @default.
• W2394987254 countsByYear W23949872542018 @default.
• W2394987254 countsByYear W23949872542019 @default.
• W2394987254 countsByYear W23949872542020 @default.
• W2394987254 countsByYear W23949872542021 @default.
• W2394987254 countsByYear W23949872542022 @default.
• W2394987254 countsByYear W23949872542023 @default.
• W2394987254 crossrefType "journal-article" @default.
• W2394987254 hasAuthorship W2394987254A5002183557 @default.
• W2394987254 hasAuthorship W2394987254A5006866490 @default.
• W2394987254 hasAuthorship W2394987254A5019174432 @default.
• W2394987254 hasAuthorship W2394987254A5043540405 @default.
• W2394987254 hasAuthorship W2394987254A5048573821 @default.
• W2394987254 hasAuthorship W2394987254A5050526088 @default.
• W2394987254 hasAuthorship W2394987254A5060383367 @default.
• W2394987254 hasAuthorship W2394987254A5076739762 @default.
• W2394987254 hasBestOaLocation W23949872541 @default.
• W2394987254 hasConcept C104317684 @default.
• W2394987254 hasConcept C135763542 @default.
• W2394987254 hasConcept C147483822 @default.
• W2394987254 hasConcept C159047783 @default.
• W2394987254 hasConcept C203014093 @default.
• W2394987254 hasConcept C2522874641 @default.
• W2394987254 hasConcept C2780040827 @default.
• W2394987254 hasConcept C2780777367 @default.
• W2394987254 hasConcept C2781096931 @default.
• W2394987254 hasConcept C3020491458 @default.
• W2394987254 hasConcept C55493867 @default.
• W2394987254 hasConcept C71924100 @default.
• W2394987254 hasConcept C86803240 @default.
• W2394987254 hasConceptScore W2394987254C104317684 @default.
• W2394987254 hasConceptScore W2394987254C135763542 @default.
• W2394987254 hasConceptScore W2394987254C147483822 @default.
• W2394987254 hasConceptScore W2394987254C159047783 @default.
• W2394987254 hasConceptScore W2394987254C203014093 @default.
• W2394987254 hasConceptScore W2394987254C2522874641 @default.
• W2394987254 hasConceptScore W2394987254C2780040827 @default.
• W2394987254 hasConceptScore W2394987254C2780777367 @default.
• W2394987254 hasConceptScore W2394987254C2781096931 @default.
• W2394987254 hasConceptScore W2394987254C3020491458 @default.
• W2394987254 hasConceptScore W2394987254C55493867 @default.
• W2394987254 hasConceptScore W2394987254C71924100 @default.
• W2394987254 hasConceptScore W2394987254C86803240 @default.
• W2394987254 hasFunder F4320311052 @default.
• W2394987254 hasIssue "3" @default.
• W2394987254 hasLocation W23949872541 @default.
• W2394987254 hasLocation W23949872542 @default.
• W2394987254 hasOpenAccess W2394987254 @default.
• W2394987254 hasPrimaryLocation W23949872541 @default.
• W2394987254 hasRelatedWork W1964148618 @default.
• W2394987254 hasRelatedWork W2004788301 @default.
• W2394987254 hasRelatedWork W2017876935 @default.
• W2394987254 hasRelatedWork W2024186628 @default.
• W2394987254 hasRelatedWork W2155980966 @default.
• W2394987254 hasRelatedWork W2162966408 @default.
• W2394987254 hasRelatedWork W2168295181 @default.
• W2394987254 hasRelatedWork W2295092829 @default.
• W2394987254 hasRelatedWork W2475154034 @default.

• next