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- W2394992025 abstract "Abstract Xanthomonas oryzae pv. oryzae ( Xoo ) is the causal agent of rice blight disease as well as a serious phytopathogen worldwide. It is also one of the model organisms for studying bacteria-plant interactions. Current progress in bacterial signal transduction pathways has identified cyclic di-GMP as a major second messenger molecule in controlling Xanthomonas pathogenicity. However, it still remains largely unclear how c-di-GMP regulates the secretion of bacterial virulence factors in Xoo . In this study, we focused on the important roles played by DgcA (XOO3988), one of our previously identified diguanylate cyclases in Xoo , through further investigating the phenotypes of several dgcA -related mutants, namely, the dgcA -knockout mutant Δ dgcA , the dgcA overexpression strain O dgcA , the dgcA complemented strain C dgcA and the wild-type strain. The results showed that dgcA negatively affected virulence, EPS production, bacterial autoaggregation and motility, but positively triggered biofilm formation via modulating the intracellular c-di-GMP levels. RNA-seq data further identified 349 differentially expressed genes controlled by DgcA, providing a foundation for a more solid understanding of the signal transduction pathways in Xoo . Collectively, the present study highlights DgcA as a major regulator of Xoo virulence and can serve as a potential target for preventing rice blight diseases." @default.
- W2394992025 created "2016-06-24" @default.
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- W2394992025 date "2016-05-19" @default.
- W2394992025 modified "2023-10-16" @default.
- W2394992025 title "DgcA, a diguanylate cyclase from Xanthomonas oryzae pv. oryzae regulates bacterial pathogenicity on rice" @default.
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- W2394992025 doi "https://doi.org/10.1038/srep25978" @default.
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