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- W2395013485 abstract "The effects of fasting and of histamine (H 2 ) antagonists on gastric volume and acidity were studied in 56 baboons undergoing various surgical procedures under general anesthesia and randomly allocated into 4 groups; group A—fasted for 14 hours; group B—given 100‐120 ml of water 3 hours before surgery; groups C and D—also given 100‐120 ml of water 3 hours before surgery; in addition, the former received cimetidine 10 mg/kg IM and the latter ranitidine 1.5 mg/kg IM 30‐40 minutes before anesthesia. There were no significant differences between groups A and B with respect to the gastric volume and pH. Both ranitidine and cimetidine significantly ( P < 0.02) reduced gastric volume and increased gastric pH. Thus, prolonged withholding of oral fluids does not reduce the gastric volume or increase gastric pH. H 2 ‐antagonists are effective in reducing both gastric residual volume and pH." @default.
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- W2395013485 date "1992-09-01" @default.
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- W2395013485 title "Is preoperative fasting necessary?" @default.
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- W2395013485 doi "https://doi.org/10.1111/j.1600-0684.1992.tb00602.x" @default.
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