FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2395035467> ?p ?o ?g. }

• W2395035467 endingPage "582" @default.
• W2395035467 startingPage "577" @default.
• W2395035467 abstract "Pathogenic streptococci express surface proteins that bind to host serum proteins. A novel multiple-ligand-binding protein has now been identified in a species belonging to serotype C streptococci. This protein binds to fibrinogen, albumin and IgG and was therefore designated FAI protein. The structure of the fai gene has been determined, and deletion analysis and expression of FAI fusion polypeptides revealed that the binding domain for fibrinogen and IgG is located within the non-repetitive N-terminal half of the protein. A 93-amino acid peptide retained the ability to bind both proteins, whereas a 56-amino acid subpeptide only bound fibrinogen. IgG-binding activity required the complete fibrinogen-binding domain and an additional 37 amino acids C-terminal to it, and albumin-binding activity was only obtained with a polypeptide reflecting the complete surface-exposed region of FAI protein indicating that the binding sites for each ligand were located on overlapping modules. Signal sequence, C repeat region and C-terminus revealed high homology to group A streptococcal M proteins whereas the N-terminal region containing the fibrinogen/IgG-binding domains is completely different and exhibits no similarity to any other previously characterized protein. Thus FAI protein exhibits a framework structure that might have evolved in group C streptococci via fusion of unrelated sequences, thereby generating an albumin-binding domain in the functional context of multiple-ligand-binding activity." @default.
• W2395035467 created "2016-06-24" @default.
• W2395035467 creator A5039643532 @default.
• W2395035467 creator A5046541623 @default.
• W2395035467 creator A5084142881 @default.
• W2395035467 date "1996-04-15" @default.
• W2395035467 modified "2023-09-25" @default.
• W2395035467 title "Structure of a group C streptococcal protein that binds to fibrinogen, albumin and immunoglobulin G via overlapping modules" @default.
• W2395035467 cites W1520670414 @default.
• W2395035467 cites W1544101325 @default.
• W2395035467 cites W1554288134 @default.
• W2395035467 cites W1555362488 @default.
• W2395035467 cites W1597302506 @default.
• W2395035467 cites W1607549514 @default.
• W2395035467 cites W1624691348 @default.
• W2395035467 cites W1679411437 @default.
• W2395035467 cites W1755546192 @default.
• W2395035467 cites W1844658740 @default.
• W2395035467 cites W1885277122 @default.
• W2395035467 cites W1903452858 @default.
• W2395035467 cites W1935933547 @default.
• W2395035467 cites W1951310736 @default.
• W2395035467 cites W1953136289 @default.
• W2395035467 cites W1978134609 @default.
• W2395035467 cites W1987225684 @default.
• W2395035467 cites W1992970973 @default.
• W2395035467 cites W1999050773 @default.
• W2395035467 cites W2000382342 @default.
• W2395035467 cites W2009387111 @default.
• W2395035467 cites W2015014029 @default.
• W2395035467 cites W2015184554 @default.
• W2395035467 cites W2021608793 @default.
• W2395035467 cites W2021723924 @default.
• W2395035467 cites W2027611515 @default.
• W2395035467 cites W2033556541 @default.
• W2395035467 cites W2034666958 @default.
• W2395035467 cites W2038193703 @default.
• W2395035467 cites W2044948212 @default.
• W2395035467 cites W2045925123 @default.
• W2395035467 cites W2049330390 @default.
• W2395035467 cites W2085545970 @default.
• W2395035467 cites W2095981560 @default.
• W2395035467 cites W2117764630 @default.
• W2395035467 cites W2136192267 @default.
• W2395035467 cites W2138139293 @default.
• W2395035467 cites W2147374678 @default.
• W2395035467 cites W2147784642 @default.
• W2395035467 cites W2148325590 @default.
• W2395035467 cites W2161308962 @default.
• W2395035467 cites W2162140882 @default.
• W2395035467 cites W2162393208 @default.
• W2395035467 doi "https://doi.org/10.1042/bj3150577" @default.
• W2395035467 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1217235" @default.
• W2395035467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8615832" @default.
• W2395035467 hasPublicationYear "1996" @default.
• W2395035467 type Work @default.
• W2395035467 sameAs 2395035467 @default.
• W2395035467 citedByCount "31" @default.
• W2395035467 countsByYear W23950354672013 @default.
• W2395035467 countsByYear W23950354672014 @default.
• W2395035467 countsByYear W23950354672015 @default.
• W2395035467 countsByYear W23950354672019 @default.
• W2395035467 countsByYear W23950354672023 @default.
• W2395035467 crossrefType "journal-article" @default.
• W2395035467 hasAuthorship W2395035467A5039643532 @default.
• W2395035467 hasAuthorship W2395035467A5046541623 @default.
• W2395035467 hasAuthorship W2395035467A5084142881 @default.
• W2395035467 hasBestOaLocation W23950354672 @default.
• W2395035467 hasConcept C104317684 @default.
• W2395035467 hasConcept C107824862 @default.
• W2395035467 hasConcept C116569031 @default.
• W2395035467 hasConcept C123894998 @default.
• W2395035467 hasConcept C135604509 @default.
• W2395035467 hasConcept C153911025 @default.
• W2395035467 hasConcept C159654299 @default.
• W2395035467 hasConcept C167625842 @default.
• W2395035467 hasConcept C170493617 @default.
• W2395035467 hasConcept C25166345 @default.
• W2395035467 hasConcept C2776125364 @default.
• W2395035467 hasConcept C2779036427 @default.
• W2395035467 hasConcept C40767141 @default.
• W2395035467 hasConcept C515207424 @default.
• W2395035467 hasConcept C51639874 @default.
• W2395035467 hasConcept C54355233 @default.
• W2395035467 hasConcept C553089730 @default.
• W2395035467 hasConcept C55493867 @default.
• W2395035467 hasConcept C86803240 @default.
• W2395035467 hasConcept C88532467 @default.
• W2395035467 hasConceptScore W2395035467C104317684 @default.
• W2395035467 hasConceptScore W2395035467C107824862 @default.
• W2395035467 hasConceptScore W2395035467C116569031 @default.
• W2395035467 hasConceptScore W2395035467C123894998 @default.
• W2395035467 hasConceptScore W2395035467C135604509 @default.
• W2395035467 hasConceptScore W2395035467C153911025 @default.
• W2395035467 hasConceptScore W2395035467C159654299 @default.
• W2395035467 hasConceptScore W2395035467C167625842 @default.
• W2395035467 hasConceptScore W2395035467C170493617 @default.
• W2395035467 hasConceptScore W2395035467C25166345 @default.

• next