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- W2395095964 abstract "Abstract Spinal cord injury (SCI) is a serious and debilitating issue being suffered by wide population worldwide. Extensive treatment approaches have been tested and being verified for their efficacy. Owing to the nature of central nervous system (CNS), the resident stem cells would be triggered in response to any sort of trauma with nerve factors as their communication signals. Apart from physical injuries, damages due to oxidative stress also need to be addressed while CNS repair mechanism takes place. This study looks at the potential of glial derived nerve factor (GDNF) in addressing the SCI in regard to oxidative damages. A total of 60 Wistar rats were clustered into five groups and GDNF at various concentrations was tested in each group. Assessments in terms of oxidative stress parameters were noted and analyzed accordingly. It was noted that GDNF had reduced oxidative damages and increased the levels of anti-oxidants in dose-dependent manner ( p" @default.
- W2395095964 created "2016-06-24" @default.
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- W2395095964 date "2016-05-01" @default.
- W2395095964 modified "2023-10-18" @default.
- W2395095964 title "Treatment with glial derived neurotropic factor (GDNF) attenuates oxidative damages of spinal injury in rat model" @default.
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- W2395095964 doi "https://doi.org/10.1016/j.jsps.2016.04.016" @default.
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