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- W2395224669 abstract "Unlike mammalian B cells, B cells in the chicken develop in a single wave of differentiation, beginning with the commitment of progenitor cells to the B cell lineage between days 10 and 15 of embryogenesis. By day 18 of embryogenesis, all lymphoid progenitor cells capable of differentiation along the B cell lineage migrate to the bursa of Fabricius. By the end of this period, chickens are able to mount primary immune responses against virtually all antigens. In addition, by this time sufficient numbers of B cells migrate from the bursa to peripheral lymphoid organs so that the B cell immune system can be maintained even if the bird is bursectomized. Because of the central nature of the surface immunoglobulin (Ig) molecule to B cell development in mammals, the chicken immunoglobulin light (IgL) gene locus is intensively studied during avian B cell development. The chicken IgL locus is of particular interest because it has only one V region capable of rearrangement. Rearrangement of the IgL gene is not dependent on the bursal environment. B cell progenitors rearrange their IgL gene between days 10–15 of embryogenesis, prior to migration to the bursa. Rearrangement of a single functional VL gene segment and subsequent diversification by gene conversion appear to be general mechanisms for the generation of IgL diversity in a wide variety of avian species. The chicken IgH locus, like the IgL locus, appears to generate only very limited diversity by recombination. There is a single functional V gene capable of rearranging with one of a cluster of D region segments and a single J region segment." @default.
- W2395224669 created "2016-06-24" @default.
- W2395224669 creator A5039348009 @default.
- W2395224669 creator A5053752263 @default.
- W2395224669 date "1990-01-01" @default.
- W2395224669 modified "2023-09-30" @default.
- W2395224669 title "Somatic Diversification of the Chicken" @default.
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- W2395224669 doi "https://doi.org/10.1016/s0065-2776(08)60751-8" @default.
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